Ong KK

No ORCID on file · 6 papers in corpus · active 2015-2024
2024
Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity.
Human reproduction (Oxford, England) ·doi:10.1093/humrep/dead247

Study questionWhich genetic factors regulate female propensity for giving birth to spontaneous dizygotic (DZ) twins?Summary answerWe identified four new loci, GNRH1, FSHR, ZFPM1, and IPO8, in addition to previously identified loci, FSHB and…

2021
Identification of methylation changes associated with positive and negative growth deviance in Gambian infants using a targeted methyl sequencing approach of genomic DNA.
FASEB bioAdvances ·doi:10.1096/fba.2020-00101

Low birthweight and reduced height gain during infancy (stunting) may arise at least in part from adverse early life environments that trigger epigenetic reprogramming that may favor survival. We examined differential DNA methylation patter…

2016
Genome-wide analysis identifies 12 loci influencing human reproductive behavior.
Nature genetics ·doi:10.1038/ng.3698

The genetic architecture of human reproductive behavior-age at first birth (AFB) and number of children ever born (NEB)-has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, …

2016
Genome-wide associations for birth weight and correlations with adult disease.
Nature ·doi:10.1038/nature19806

Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in observational studies is reproducibly associated with future risk of adult metabolic diseases including type 2 diabetes (T2D) and cardiovascular dis…

2015
New genetic loci link adipose and insulin biology to body fat distribution.
Nature ·doi:10.1038/nature14132

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links…

2015
Puberty timing associated with diabetes, cardiovascular disease and also diverse health outcomes in men and women: the UK Biobank study.
Scientific reports ·doi:10.1038/srep11208

Early puberty timing is associated with higher risks for type 2 diabetes (T2D) and cardiovascular disease in women and therefore represents a potential target for early preventive interventions. We characterised the range of diseases and ot…