Guo X

BackgroundAtrial fibrillation (AF) and ovarian cancer are leading causes of morbidity, with emerging evidence suggesting potential interplay. However, their temporal and genetic relationships remain unclear.MethodsWe analyzed 265,248 women …

STUDY QUESTION: How can the potential mechanisms and targets of endometriosis be explored through multi-omics and multi-location approaches? SUMMARY ANSWER: This exploration of the gut-reproductive axis in patients with endometriosis found…

BackgroundPrimary dysmenorrhea is fundamentally driven by uterine ischemia resulting from excessive vascular resistance. While acupuncture is theorized to improve perfusion, high-quality evidence controlling for pharmacological confounders …

Endometriosis diagnosis is often limited by the resolution of conventional imaging techniques (ultrasound/non-targeted MRI) as well as the invasiveness and recurrence risks associated with laparoscopy. To overcome these challenges, we devel…

BACKGROUNDS: Abnormal cleavage (ABNCL) in early human embryos is a frequent phenomenon associated with impaired developmental competence and reduced reproductive potential. However, the clinical determinants of ABNCL and its subtypes remain…

BACKGROUND: Chronic pain resulting from postoperative adhesions represents a significant clinical concern due to its substantial impact on patient quality of life; however, optimal therapeutic management remains contentious. This systematic…

This study investigates the role of carbohydrate antigen 125 (CA125) in the pathogenesis of systemic lupus erythematosus (SLE) and analyzes factors associated with its elevation. A total of 220 patients diagnosed with SLE at the Department …

BackgroundOrganochlorine pesticides (OCPs) are extensively dispersed throughout the environment, which potentially have harmful impacts on the female reproductive system. Therefore, the purpose of this study was to clarify the association b…

ObjectiveTo explore the role of endometrial defects in the pathogenesis of abnormal uterine bleeding (AUB).DesignRetrospective case-control study.SettingTwo tertiary centres.Population or sampleWe included 155 patients with caesarean scar d…

Hepatocellular carcinoma (HCC) mainly depends on liver fibrosis/cirrhosis, which is regulated by tumor cells and the tumor microenvironment (TME), and is a crucial factor in tumor progression. This study aimed to identify abnormally express…

BackgroundTo investigate the predictive role of a risk assessment model constructed using Caprini score combined with D-dimer in gynecological postoperative patients for the occurrence of deep vein thrombosis.MethodsPatients scheduled for g…

Spatial transcriptomics enables in situ molecular profiling, allowing to measure the cellular transcriptional output within the tissue. As the tissue architecture is conserved, spatial domains with specific transcriptional patterns can be i…

Objective: To synthesize the multifactorial determinants of fertility distress among reproductive-aged women with gynecological cancers, elucidating complex interactions among biological, psychological, and sociocultural dimensions. Methods…

Granulosa cell (GC) dysfunction contributes to diminished ovarian reserve (DOR). We collected GC and follicular fluid samples from the patients of normal ovarian reserve (NOR) and DOR. RNA-seq of GCs showed that cholesterol/sterol metabolis…

ContextFK506-binding-protein-51 (FKBP51) is a glucocorticoid-induced co-chaperone protein previously shown to bind glucocorticoid receptor (GR), inhibiting its transcriptional activity. We previously found increased FKBP51 levels in uterine…

The studies on how mast cells mediate endometriosis pain are still limited. Mas-related G protein-coupled receptor member X2 (MRGPRX2), a receptor expressed on mast cells, participates in pain, inflammation, and itch. However, it is still u…

BackgroundTesticular torsion is defined as an acute scrotal emergency that occurs in adolescents. It requires intervention within 6 h to avoid necrosis due to ischemia of the testis caused by seminal torsion. The etiology of testicular tors…

BackgroundHydroxyurea (HU) is an antitumor drug. However, HU exposure is associated with diminished ovarian reserve (DOR). Zi Chong granules, a Chinese Medicine, can protect against DOR, but little is known regarding its underlying mechanis…

OBJECTIVE: To report a rare case of multiple subserous uterine adenomyomas diagnosed and treated by laparoscopy. CASE REPORT: A premenopausal 55-year-old woman was admitted presenting with bilateral adnexal cysts. Preoperative ultrasound a…

Huali Fei,1 Xiaoyan Guo,2 Jin Li,2 Xuejing Jin1 1Department of Reproductive Endocrinology, Hangzhou Women’s Hospital, Hangzhou, People’s Republic of China; 2Department of Gynecology, Hangzhou Women’s Hospital, Hangzhou, People’s Republic of…

PurposeProtectin D1 (PD1), a biologically active molecule derived from docosahexaenoic acid (DHA), plays a major role in the body's endogenous lipid-mediated inflammatory response. The study aims to explore the relationship between PD1, inf…

BackgroundIn the past quite a long time, intraoperative cholangiography(IOC)was necessary during laparoscopic cholecystectomy (LC). Now magnetic resonance cholangiopancreatography (MRCP) is the main method for diagnosing common bile duct st…

OBJECTIVE: To study the effect of adenomyosis on the localized expression of the GATA binding proteins 2 and 6 (GATA2 and GATA6) zinc-finger transcription factors that are involved in proliferation of hematopoietic and endocrine cell lineag…

IntroductionCardiac arrest during pregnancy is receiving increasing attention. However, there are few reports on cardiac arrest in nonpregnant women caused by abnormal uterine bleeding (AUB). We report a case in which extracorporeal cardiop…