Zhang C

BackgroundOvarian sex cord-stromal tumors (OSCSTs) are a rare and heterogeneous group of ovarian neoplasms, encompassing various subtypes such as ovarian thecoma, fibroma (including cellular fibroma), and ovarian granulosa cell tumors (OGCT…

BackgroundAccurate early diagnosis of ovarian cancer is crucial. The objective of this research is to create a comprehensive model that merges clinical variables, O-RADS, and deep learning radiomics to support preoperative diagnosis and ass…

ObjectiveTo explore the micro blood flow characteristics of normal singleton pregnancy placenta in middle and late pregnancy based on microvascular flow (MV-Flow) imaging.MethodsWe conducted a retrospective cohort study. Clinical records an…

Ferroptosis, as an iron-dependent programmed cell death, plays a significant role in reproductive system diseases. It's involved in the pathological processes of various reproductive system diseases by affecting the survival status of germ …

BACKGROUND: Endometriosis is a common, chronic, estrogen-dependent gynecological disorder that significantly affects patients' quality of life. However, the disease burden and its trends may be undergoing significant changes, and comprehens…

Background: Both intramural myomas and thin endometrium exert a detrimental influence on the outcomes of assisted reproductive technology (ART). The downregulation of gonadotropin releasing hormone agonists (GnRH-a) is regarded as an effect…

Recent advances in understanding the modulatory functions of gut and gut microbiota on human diseases facilitated our focused attention on the contribution of the gut to the pathophysiological alterations of many extraintestinal organs, inc…

BACKGROUND: Hypoxia plays a critical role in both physiological and pathological processes. Cells adapt to hypoxia through the extensive reprogramming of gene expression. While the transcriptional regulations of hypoxia-inducible factors (H…

BACKGROUND: Endometriosis is a common benign gynecologic disease in women of reproductive age, and its manifestations remarkably decrease quality of life. Lactate, as a metabolite, exerts prominent effects across a wide range of biological …

Endocrine disrupting chemicals (EDCs) are ubiquitous in the environment and have been shown to interfere with the endocrine system, leading to adverse effects on reproductive health. In females, EDC exposure has been linked to menstrual irr…

ObjectiveThis study investigated the impact of blastocyst developmental stage and morphological grading on pregnancy outcomes following single euploid frozen-thawed blastocyst transfer (SE-FBT) in young patients with recurrent pregnancy los…

BackgroundAMH is a dependable indicator of ovarian reserve function and assessment of ovarian responsiveness. The relationship between reduced ovarian reserve and pregnancy loss remains poorly understood and requires further investigation. …

BACKGROUND: Endometriosis (EMs) is a persistent inflammatory condition whose three main symptoms, mass, pain, and infertility, severely affect female patients of childbearing age. Hu-Po-San (HPS), a preparation consisting of various herbal …

Gynecologic cancers (GCs), including cervical cancer (CC), ovarian cancer (OC), endometrial cancer (EC), as well as vulvar and vaginal cancers, represent major health threats to women, with increasing incidence rates observed globally. Conv…

IntroductionUterine sarcoma (US) is a rare tumor characterized by high aggressiveness, a tendency for recurrence and distant metastasis, and an extremely poor prognosis. In this study, we evaluated the expression of Orosomucoid 1 (ORM1) in …

Lymph node metastasis (LNM) confers significant treatment failure and adverse clinical outcomes in cervical cancer (CCa). However, large unknown lies in the mechanisms underlying LNM in CCa. In this study, we discovered that PRDX3 is elevat…

BackgroundTo investigate the optimal periendometrial zone (PEZ) in ultrasound (US) images and assess the performance of ultrasound radiomics in predicting the outcome of frozen embryo transfer (FET).MethodsThis prospective study had 422 fem…

ObjectiveTo assess the efficacy of preimplantation genetic testing for aneuploidies (PGT-A) compared to intracytoplasmic sperm injection (ICSI) alone in couples undergoing ICSI treatment because of severe male infertility.DesignMulticentre,…

We present the case of a 39-year-old Chinese woman who presented with a palpable mass in her abdominal wall and pelvic cavity 9 years after undergoing laparoscopic myomectomy. Six abdominal wall fibroids, 18 intramural fibroids, 1 posterior…

Abstract Objective To analyze the clinical characteristics of hospitalized patients with benign gallbladder diseases based on a large dataset, and compare these findings with those from the physical examination population in existing liter…

Osteopontin (OPN) is an extracellular matrix protein secreted by various types of cells, and serves multiple physiological roles such as modulating bone cell maturation, immune responses, tissue repair and regeneration. Aberrant OPN express…

ObjectiveTo evaluate the dynamics of serum medroxyprogesterone acetate (MPA) concentrations and their influence on serum progesterone (P) levels and pregnancy outcomes in the progestin-primed ovarian stimulation (PPOS) protocol. A total of …

Endometriosis (EMs) is a gynecological disorder characterized by chronic inflammation and an aberrant immune microenvironment. In this study, we integrated the GSE6364 dataset from the GEO database to identify differentially expressed genes…

The objective was to assess outcomes of robotic-assisted transvaginal natural orifice transluminal endoscopic surgery (RA-vNOTES) performed for hysterectomy and endometriosis excision. We conducted a retrospective case series across two hos…