Szwarc MM

No ORCID on file · 9 papers in corpus · active 2013-2022

Study types

  • review 2
  • article 1
  • other 1

Condition tags

  • endometriosis 4
  • infertility 3
2022
Decidualization of human endometrial stromal cells requires steroid receptor coactivator-3.
Frontiers in reproductive health ·doi:10.3389/frph.2022.1033581

Steroid receptor coactivator-3 (SRC-3; also known as NCOA3 or AIB1) is a member of the multifunctional p160/SRC family of coactivators, which also includes SRC-1 and SRC-2. Clinical and cell-based studies as well as investigations on mice h…

article 2022
Early growth response 1 transcription factor is essential for the pathogenic properties of human endometriotic epithelial cells
Reproduction (Cambridge, England) ·doi:10.1530/rep-22-0123

Although a non-malignant gynecological disorder, endometriosis displays some pathogenic features of malignancy, such as cell proliferation, migration, invasion and adaptation to hypoxia. Current treatments of endometriosis include pharmacot…

2018
Uterine function in the mouse requires speckle-type poz protein.
Biology of reproduction ·doi:10.1093/biolre/ioy060

Speckle-type poz protein (SPOP) is an E3-ubiquitin ligase adaptor for turnover of a diverse number of proteins involved in key cellular processes such as chromatin remodeling, transcriptional regulation, and cell signaling. Genomic analysis…

2017
Growth regulation by estrogen in breast cancer 1 (GREB1) is a novel progesterone-responsive gene required for human endometrial stromal decidualization.
Molecular human reproduction ·doi:10.1093/molehr/gax045

Study questionIs Growth Regulation by Estrogen in Breast Cancer 1 (GREB1) required for progesterone-driven endometrial stromal cell decidualization?Summary answerGREB1 is a novel progesterone-responsive gene required for progesterone-driven…

other 2015
Reprint of "Steroid receptor coactivators as therapeutic targets in the female reproductive system"
The Journal of steroid biochemistry and molecular biology ·doi:10.1016/j.jsbmb.2015.08.012

The steroid receptor coactivators (SRCs/p160/NCOA) are a family of three transcriptional coregulators initially discovered to transactivate the transcriptional potency of steroid hormone receptors. Even though SRCs were also found to modula…

review 2015
Steroid receptor coactivators as therapeutic targets in the female reproductive system
The Journal of steroid biochemistry and molecular biology ·doi:10.1016/j.jsbmb.2015.06.010

The steroid receptor coactivators (SRCs/p160/NCOA) are a family of three transcriptional coregulators initially discovered to transactivate the transcriptional potency of steroid hormone receptors. Even though SRCs were also found to modula…

2014
Perturbing the cellular levels of steroid receptor coactivator-2 impairs murine endometrial function.
PloS one ·doi:10.1371/journal.pone.0098664

As pleiotropic coregulators, members of the p160/steroid receptor coactivator (SRC) family control a broad spectrum of transcriptional responses that underpin a diverse array of physiological and pathophysiological processes. Because of the…

review 2014
The p160/steroid receptor coactivator family: potent arbiters of uterine physiology and dysfunction
Biology of reproduction ·doi:10.1095/biolreprod.114.125021

The p160/steroid receptor coactivator (SRC) family comprises three pleiotropic coregulators (SRC-1, SRC-2, and SRC-3; otherwise known as NCOA1, NCOA2, and NCOA3, respectively), which modulate a wide spectrum of physiological responses and c…

2013
Acceleration of the glycolytic flux by steroid receptor coactivator-2 is essential for endometrial decidualization.
PLoS genetics ·doi:10.1371/journal.pgen.1003900

Early embryo miscarriage is linked to inadequate endometrial decidualization, a cellular transformation process that enables deep blastocyst invasion into the maternal compartment. Although much of the cellular events that underpin endometr…