Xi Chen

ORCID: 0000-0002-3013-4558 · 8 papers in corpus
article 2026
VGG11-based deep learning for automated MRI classification of adenomyosis: a systematic comparison of five classification criteria
·doi:10.1186/s12880-026-02633-4

Magnetic resonance imaging (MRI) has been increasingly applied in the classification of adenomyosis; however, due to the lack of a standardized gold standard for lesion classification, it remains challenging to make an early diagnosis and i…

other 2025
Endometrial Mesenchymal Stem Cell-Derived Exosomal miR-4669 Promotes EMT in Adenomyosis by Inducing M2 Macrophage Polarization via the DUSP6/ERK Pathway
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1007/s43032-025-01944-1

Adenomyosis (AM), a gynecological disorder that severely affects female reproductive health. AM-associated macrophage (AAM) polarization-induced epithelial-mesenchymal transition (EMT) is a key driver of AM progression. In this study, we in…

article 2025
Safety and efficacy of subcutaneous injection with HMI-115 versus placebo in endometriosis-associated pain in premenopausal women: a multicentre, double-blind, randomised, proof-of-concept phase 2 trial
·doi:10.1016/j.lanogw.2025.100032
article 2024
C5aR1+ macrophages are involved in the progression of endometriosis
·doi:10.1097/rd9.0000000000000120

Objective: Immune dysfunction plays an important role in the pathogenesis of endometriosis. C5a, a by-product of complement activation, binds to its receptor (C5a receptor 1, C5aR1) in various cells, including macrophages. The combination o…

article 2023
Warming Menstruation and Analgesic Soup Inhibits PD-1/PD-L1 Pathway in Rats with Endometriosis
Alternative therapies in health and medicine

AIM: To observe the effect of warming menstruation and analgesic herbal soup (WMAS) on the pathway of programmed cell death protein 1 and its ligand 1 PD-1/PD-L1 in rats with endometriosis model. METHODS: A total of 90 mature female Wistar…

article 2022
Melatonin suppresses bone marrow adiposity in ovariectomized rats by rescuing the imbalance between osteogenesis and adipogenesis through SIRT1 activation
·doi:10.1016/j.jot.2022.10.002

Introduction: Accelerated imbalance between bone formation and bone resorption is associated with bone loss in postmenopausal osteoporosis. Studies have shown that this loss is accompanied by an increase in bone marrow adiposity. Melatonin …

article 2017
Transforming Growth Factor-beta 1 Involved in the Pathogenesis of Endometriosis through Regulating Expression of Vascular Endothelial Growth Factor under Hypoxia
Chinese medical journal ·doi:10.4103/0366-6999.204112

BACKGROUND: Endometriosis (EMs) is a common gynecological disorder characterized by endometrial-like tissue outside the uterus. Hypoxia induces the expression of many important downstream genes to regulate the implantation, survival, and ma…

2011
Human xeno-autoantibodies against a non-human sialic acid serve as novel serum biomarkers and immunotherapeutics in cancer.
Cancer research ·doi:10.1158/0008-5472.can-10-4102

Human carcinomas can metabolically incorporate and present the dietary non-human sialic acid Neu5Gc, which differs from the human sialic acid N-acetylneuraminic acid (Neu5Ac) by 1 oxygen atom. Tumor-associated Neu5Gc can interact with low l…