Edwards AK

No ORCID on file · 9 papers in corpus · active 2012-2016

Study types

  • article 5
  • other 2
  • review 1

Condition tags

  • endometriosis 8
  • infertility 2
  • dysmenorrhea 1
  • dyspareunia 1
other 2016
Chronic effects of an anti-angiogenic thrombospondin-1 mimetic peptide, ABT-898, on female mouse reproductive outcomes
Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-016-0192-7

BACKGROUND: Angiogenesis is an essential process in endometriosis disease progression. Earlier, we demonstrated that anti-angiogenic peptide, ABT-898 prevents neoangiogenesis of human endometriotic lesions in a xenograft mouse model. Since …

other 2016
Surgical removal of endometriotic lesions alters local and systemic proinflammatory cytokines in endometriosis patients
Fertility and sterility ·doi:10.1016/j.fertnstert.2015.11.047

OBJECTIVE: To determine the impact of endometriotic lesion removal on local and systemic inflammation. DESIGN: Multiplex cytokine analysis on samples from endometriosis patients before surgery, 2 weeks after surgery, and 3 months after sur…

article 2015
Compatibility of a Novel Thrombospondin-1 Analog with Fertility and Pregnancy in a Xenograft Mouse Model of Endometriosis
PloS one ·doi:10.1371/journal.pone.0121545

Endometriosis is a gynecological disease defined by the growth of endometrium outside of the uterus. Although endometriosis contributes to 50% of female infertility cases, medical treatments are incompatible with pregnancy. Angiogenesis, th…

article 2015
IL-17A Contributes to the Pathogenesis of Endometriosis by Triggering Proinflammatory Cytokines and Angiogenic Growth Factors
Journal of immunology (Baltimore, Md. : 1950) ·doi:10.4049/jimmunol.1501138

Endometriosis is a chronic, inflammatory disease characterized by the growth of endometrial tissue in aberrant locations outside the uterus. Neoangiogenesis or establishment of new blood supply is one of the fundamental requirements of endo…

article 2014
A peptide inhibitor of synuclein-  reduces neovascularization of human endometriotic lesions
Molecular human reproduction ·doi:10.1093/molehr/gau054

Endometriosis is a chronic painful gynecological condition characterized by adherence and growth of endometrium outside of the uterine cavity. Neovascularization is essential to the developing endometriosis lesion to support its growth. Syn…

review 2013
Animal models for anti-angiogenic therapy in endometriosis
Journal of reproductive immunology ·doi:10.1016/j.jri.2012.10.012

Endometriosis is a gynecological disease characterized by the growth of endometrium outside of the uterine cavity. It is often associated with dysmenorrhea, dyspareunia, pelvic pain and infertility. One of the key requirements for endometri…

article 2013
Blocking of Stromal Cell-Derived Factor-1 Reduces Neoangiogenesis in Human Endometriosis Lesions in a Mouse Model
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/aji.12134

PROBLEM: Endometriosis affects 5-10% of women and is characterized by the growth of endometrial tissue outside of the uterus. Establishing new blood supply is a fundamental requirement for endometriosis lesion growth. Endothelial progenitor…

2013
The microRNAome of pregnancy: deciphering miRNA networks at the maternal-fetal interface.
PloS one ·doi:10.1371/journal.pone.0072264

MicroRNAs (miRNAs) post-transcriptionally regulate a vast network of genes by inhibiting mRNA translation. Aberrant miRNA expression profiles have been implicated in pathologies and physiological processes including pregnancy and angiogenes…

article 2012
Thrombospondin-1 Mimetic Peptide ABT-898 Affects Neovascularization and Survival of Human Endometriotic Lesions in a Mouse Model
The American journal of pathology ·doi:10.1016/j.ajpath.2012.05.010

Endometriosis is a common cause of pelvic pain and infertility in women, and a common indication for hysterectomy, yet the disease remains poorly diagnosed and ineffectively treated. Because endometriotic lesions require new blood supply fo…