Matthias W. Laschke (6855236)

No ORCID on file · 5 papers in corpus
other 2019
Alpha- and beta-diversity analyses.
·doi:10.1371/journal.pone.0226835.g002

Alpha- and beta-diversity plots to visualize the difference in bacterial microbiota structure between endometriosis and sham (control) groups 3 days before the induction of endometriosis (before EI; endometriosis: n = 8, sham: n = 6) as wel…

other 2019
Endometriosis model.
·doi:10.1371/journal.pone.0226835.g001

A: Sequence of the in vivo experiments. Endometriosis was induced on day 0 by transplantation of uterine tissue fragments from GFP+ donor animals into the peritoneal cavity of GFP- recipient mice. After 21 days, the take rate and size of ne…

other 2019
Fecal bacterial microbiota composition.
·doi:10.1371/journal.pone.0226835.g003

Relative abundances of the 10 relatively most abundant bacterial genera in endometriosis and sham (control) groups 3 days before the induction of endometriosis (before EI; endometriosis: n = 8, sham: n = 6) as well as on days 7 (endometrios…

dataset 1753
Potent Dual\nInhibitors of Steroid Sulfatase and 17β-Hydroxysteroid\nDehydrogenase Type 1 with a Suitable Pharmacokinetic Profile for In Vivo Proof-of-Principle Studies in an Endometriosis Mouse\nModel
·doi:10.1021/acs.jmedchem.3c00571.s001

Treating estrogen-dependent diseases like endometriosis\nwith drugs\nsuppressing local estrogen activation may be superior to existing\nendocrine therapies. Steroid sulfatase (STS) and 17β-hydroxysteroid\ndehydrogenase type 1 (17β-HSD1) are…

article 1753
Potent Dual\nInhibitors of Steroid Sulfatase and 17β-Hydroxysteroid\nDehydrogenase Type 1 with a Suitable Pharmacokinetic Profile for In Vivo Proof-of-Principle Studies in an Endometriosis Mouse\nModel
·doi:10.1021/acs.jmedchem.3c00571.s002

Treating estrogen-dependent diseases like endometriosis\nwith drugs\nsuppressing local estrogen activation may be superior to existing\nendocrine therapies. Steroid sulfatase (STS) and 17β-hydroxysteroid\ndehydrogenase type 1 (17β-HSD1) are…