Chun-Jie Gu

No ORCID on file · 4 papers in corpus · active 2018-2019

Study types

  • other 2
  • article 1
  • review 1

Condition tags

  • endometriosis 4
  • mesh:D004715 3
other 2019
Melatonin restricts the viability and angiogenesis of vascular endothelial cells by suppressing HIF-1α/ROS/VEGF
International journal of molecular medicine ·doi:10.3892/ijmm.2018.4021

Angiogenesis is an essential process involved in various physiological, including placentation, and pathological, including cancer and endometriosis, processes. Melatonin (MLT), a well‑known natural hormone secreted primarily in the pineal …

article 2018
Indoleamine 2,3-dioxygenase suppresses the cytotoxicity of NK cells in response to ectopic endometrial stromal cells in endometriosis
Reproduction (Cambridge, England) ·doi:10.1530/rep-18-0112

It has been reported that the impaired cytotoxicity of natural killer (NK) cells and abnormal cytokines that are changed by the interaction between ectopic endometrial cells and immune cells is indispensable for the initiation and developme…

review 2018
Pleiotropic roles of melatonin in endometriosis, recurrent spontaneous abortion, and polycystic ovary syndrome
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/aji.12839

Melatonin is a neurohormone synthesized from the aromatic amino acid tryptophan mainly by the pineal gland of mammals. Melatonin acts as a broad-spectrum antioxidant, powerful free radical scavenger, anti-inflammatory agent, anticarcinogeni…

other 2018
The ginsenoside PPD exerts anti-endometriosis effects by suppressing estrogen receptor-mediated inhibition of endometrial stromal cell autophagy and NK cell cytotoxicity
Cell death & disease ·doi:10.1038/s41419-018-0581-2

Endometriosis (EMS) is an estrogen-dependent gynecological disease with a low autophagy level of ectopic endometrial stromal cells (eESCs). Impaired NK cell cytotoxic activity is involved in the clearance obstruction of the ectopic endometr…