Kiyono T

No ORCID on file · 9 papers in corpus · active 2007-2025

Study types

  • article 5
  • other 1
  • preprint 1

Condition tags

  • endometriosis 7
  • endometrioma 2
preprint 2025
Establishment of a Novel In Vitro and In Vivo Model to Understand Molecular Carcinogenesis of Endometriosis-Related Ovarian Neoplasms
·doi:10.20944/preprints202502.0858.v1

The molecular mechanisms through which endometriosis-related ovarian neoplasms (ERONs) develop from benign endometrioma remain unclear. It is especially a long-standing mystery why ovarian endometrioma has the potential to develop into two …

2021
Endometrial regeneration with endometrial epithelium: homologous orchestration with endometrial stroma as a feeder.
Stem cell research & therapy ·doi:10.1186/s13287-021-02188-x

BackgroundThin endometrium adversely affects reproductive success rates with fertility treatment. Autologous transplantation of exogenously prepared endometrium can be a promising therapeutic option for thin endometrium; however, endometria…

article 2021
Establishment of a Novel In Vitro Model of Endometriosis with Oncogenic KRAS and PIK3CA Mutations for Understanding the Underlying Biology and Molecular Pathogenesis
Cancers ·doi:10.3390/cancers13133174

Endometriosis-harboring cancer-associated somatic mutations of PIK3CA and KRAS provides new opportunities for studying the multistep processes responsible for the functional and molecular changes in this disease. We aimed to establish a nov…

article 2020
Establishment and characterization of cell lines from human endometrial epithelial and mesenchymal cells from patients with endometriosis
F&S science ·doi:10.1016/j.xfss.2020.09.001

Objective To establish and characterize cell lines derived from human endometrial epithelial cells (ECs) and mesenchymal cells (MCs) from patients with and without endometriosis. Design In vitro experimental study. Setting University and na…

article 2014
Concurrent estrogen action was essential for maximal progestin effect in oral contraceptives
Fertility and sterility ·doi:10.1016/j.fertnstert.2014.02.005

ObjectiveTo investigate the impact of estrogen contained in oral contraceptives (OCs) on the action of progestin on ovarian endometrioma epithelial cells.DesignExperimental in vitro study and immunohistochemical analysis.SettingUniversity h…

article 2014
Dienogest, a synthetic progestin, down-regulates expression of CYP19A1 and inflammatory and neuroangiogenesis factors through progesterone receptor isoforms A and B in endometriotic cells
The Journal of steroid biochemistry and molecular biology ·doi:10.1016/j.jsbmb.2014.12.008

Dienogest (DNG) is a selective progesterone receptor (PR) agonist and oral administration of DNG is used for the treatment of endometriosis. DNG is considered to act on PR to down-regulate pathophysiological factors associated with endometr…

other 2012
Creation of immortalised epithelial cells from ovarian endometrioma
British journal of cancer ·doi:10.1038/bjc.2012.26

BACKGROUND: Epithelial cells of endometriotic tissues are difficult to propagate in vitro as experimental material is scarce owing to their limited life span. However, there is an increasing concern regarding their malignant transformation …

article 2009
Dienogest, a synthetic progestin, inhibits the proliferation of immortalized human endometrial epithelial cells with suppression of cyclin D1 gene expression
Molecular human reproduction ·doi:10.1093/molehr/gap042

Dienogest is a specific progesterone receptor agonist with potent oral endometrial activity and is used in the treatment of endometriosis. In this study, we examined the direct effects of dienogest on the proliferation of human endometrial …

2007
Menstrual blood-derived cells confer human dystrophin expression in the murine model of Duchenne muscular dystrophy via cell fusion and myogenic transdifferentiation.
Molecular biology of the cell ·doi:10.1091/mbc.e06-09-0872

Duchenne muscular dystrophy (DMD), the most common lethal genetic disorder in children, is an X-linked recessive muscle disease characterized by the absence of dystrophin at the sarcolemma of muscle fibers. We examined a putative endometria…