Wiesenfeld HC

No ORCID on file · 7 papers in corpus · active 2017-2022

Study types

  • article 1

Condition tags

  • infertility 3
  • endometriosis 1
  • disambig:endometritis 1
2022
Genetic susceptibility loci for Chlamydia trachomatis endometrial infection influence expression of genes involved in T cell function, tryptophan metabolism and epithelial integrity.
Frontiers in immunology ·doi:10.3389/fimmu.2022.1001255

ObjectivesIdentify genetic loci of enhanced susceptibility to Chlamydial trachomatis (Ct) upper genital tract infection in women.MethodsWe performed an integrated analysis of DNA genotypes and blood-derived mRNA profiles from 200 Ct-exposed…

2022
Reduced Endometrial Ascension and Enhanced Reinfection Associated With Immunoglobulin G Antibodies to Specific Chlamydia trachomatis Proteins in Women at Risk for Chlamydia.
The Journal of infectious diseases ·doi:10.1093/infdis/jiab496

BackgroundPrevious research revealed antibodies targeting Chlamydia trachomatis elementary bodies was not associated with reduced endometrial or incident infection in C. trachomatis-exposed women. However, data on the role of C. trachomatis…

2021
A Randomized Controlled Trial of Ceftriaxone and Doxycycline, With or Without Metronidazole, for the Treatment of Acute Pelvic Inflammatory Disease.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America ·doi:10.1093/cid/ciaa101

BackgroundAnaerobic organisms are important pathogens in acute pelvic inflammatory disease (PID). The currently recommended PID regimen of a single dose of ceftriaxone and doxycycline for 14 days has limited anaerobic activity. The need for…

article 2021
Chlamydial Pgp3 Seropositivity and Population-Attributable Fraction Among Women With Tubal Factor Infertility
Sexually transmitted diseases ·doi:10.1097/olq.0000000000001434

BACKGROUND: Chlamydial infection is associated with tubal factor infertility (TFI); however, assessment of prior chlamydial infection and TFI is imperfect. We previously evaluated a combination of serological assays for association with TFI…

2021
Tubal Factor Infertility, In Vitro Fertilization, and Racial Disparities: A Retrospective Cohort in Two US Clinics.
Sexually transmitted diseases ·doi:10.1097/olq.0000000000001435

BackgroundNearly 14% of US women report any lifetime infertility which is associated with health care costs and psychosocial consequences. Tubal factor infertility (TFI) often occurs as a result of sexually transmitted diseases and subseque…

2018
Gene Expression Signatures Can Aid Diagnosis of Sexually Transmitted Infection-Induced Endometritis in Women.
Frontiers in cellular and infection microbiology ·doi:10.3389/fcimb.2018.00307

Sexually transmitted infection (STI) of the upper reproductive tract can result in inflammation and infertility. A biomarker of STI-induced upper tract inflammation would be significant as many women are asymptomatic and delayed treatment i…

2017
Population-attributable fraction of tubal factor infertility associated with chlamydia.
American journal of obstetrics and gynecology ·doi:10.1016/j.ajog.2017.05.026

BackgroundChlamydia trachomatis infection is highly prevalent among young women in the United States. Prevention of long-term sequelae of infection, including tubal factor infertility, is a primary goal of chlamydia screening and treatment …