Heather Noga

PURPOSE: Deep infiltrating endometriosis (DIE) is defined as an endometriotic lesion penetrating to a depth of >5 mm and is associated with pelvic pain, but the underlying mechanisms are unclear. Our objective is to investigate whether plas…

INTRODUCTION: Pelvic pain and vulvar pain are common conditions in women. In this study, we sought to characterize the clinical picture of patients with concurrent pelvic pain and provoked vestibulodynia (PVD). AIM: To analyze the associat…

The etiology of endometriosis-associated deep dyspareunia (DD) may be due to direct disease-specific factors (e.g. location or invasiveness of disease) and/or to indirect contributors such as bladder/pelvic floor dysfunction. We aimed to de…

(Abstracted from Am J Obstet Gynecol 2018;218:114.e1–114.e12) Chronic pelvic pain (CPP) is a common clinical problem among women. Its etiology is complex and involves an interplay of gynecologic, urologic, gastrointestinal, musculoskeletal,…

INTRODUCTION: Deep dyspareunia occurs in half of women with endometriosis, a condition present in 10% of reproductive-age women and associated with negative effects on sexual quality of life (SQoL). However, women with endometriosis can hav…

INTRODUCTION: The etiology of endometriosis-associated deep dyspareunia may include direct endometriosis-specific factors (eg, stage or invasiveness of disease) and/or indirect contributors such as bladder/pelvic floor dysfunction (eg, rela…

STUDY OBJECTIVE: To investigate ethnic differences for moderate-to-severe endometriosis. DESIGN: Analysis of a prospective registry (Canadian Task Force classification II-2). SETTING: Tertiary referral center. PATIENTS: A total of 1594 w…

Endometriosis is a common gynecological disease and precursor of clear cell and endometrioid ovarian carcinomas. We recently demonstrated that one form of endometriosis with little malignant potential, deep infiltrating endometriosis (DE), …

STUDY QUESTION: Does incisional endometriosis (IE) harbor somatic cancer-driver mutations? SUMMARY ANSWER: We found that approximately one-quarter of IE cases harbor somatic-cancer mutations, which commonly affect components of the MAPK/RA…

STUDY OBJECTIVE: To evaluate the point-of-care preoperative transvaginal ultrasound (TVUS) sliding sign in comparison with palpation of a nodule on digital pelvic examination for the prediction of pouch of Douglas (POD) obliteration. DESIG…

INTRODUCTION: Deep dyspareunia is a common symptom in women, including in half of women with endometriosis, but little is known about its response to treatment and predictors of persistent deep dyspareunia over time. AIM: To follow up deep…

Endometriosis-associated pelvic pain is a common and often challenging problem. For certain patients, pain persists or recurs despite adequate medical or surgical therapy targeted to endometriosis. In this patient population, there is often…

BACKGROUND: Chronic pelvic pain affects ∼15% of women, and presents a challenging problem for gynecologists due to its complex etiology involving multiple comorbidities. Thus, an interdisciplinary approach has been proposed for chronic pelv…