Baccarelli AA

PurposeTo determine correlations between chemicals in follicular fluid (FF) and follicular reproductive hormone levels.MethodsThe analysis was part of a larger cohort study to determine associations between exposure to EDCs and in vitro fer…

Indicators of male fertility are in decline globally, but the underlying causes, including the role of environmental exposures, are unclear. This study aimed to examine organic chemical pollutants in seminal plasma, including both known pri…

PurposeTo compare the expression profile of extracellular vesicle microRNAs (EV-miRNAs) derived from follicular fluid after a trigger with recombinant human chorionic gonadotropin (r-hCG) or with a gonadotropin-releasing hormone GnRH agonis…

BackgroundExtracellular vesicles (EVs), membrane-bound particles containing a variety of RNA types, DNA, proteins, and other macromolecules, are now appreciated as an important means of communication between cells and tissues, both in norma…

Extracellular vesicles (EVs) are nano-sized membrane bound complexes that have been identified as a mean for intercellular communication between cells and tissues both in physiological and pathological conditions. These vesicles contain num…

PurposeTo assess whether machine learning methods provide advantage over classic statistical modeling for the prediction of IVF outcomes.MethodsThe study population consisted of 136 women undergoing a fresh IVF cycle from January 2014 to Au…

ObjectiveTo study whether increased body mass index is associated with altered expression of extracellular vesicle microRNAs (EV-linked miRNAs) in human follicular fluid.DesignCross-sectional study.SettingTertiary-care university-affiliated…

ObjectivesTo examine the association between phthalate exposure and two measures of uterine fibroid burden: diameter of largest fibroid and uterine volume.DesignPilot, cross-sectional study.SettingAcademic medical center.Patient(s)Fifty-sev…

Bisphenol A (BPA) is a widely used chemical that has been detected in follicular fluid and associated with adverse reproductive effects. Granulosa cells have an important role in follicular growth and oocyte maturation, however, little is k…

BackgroundPhenols and phthalates are potential endocrine disrupting chemicals (EDCs) that are associated with adverse health outcomes. These EDCs dysregulate a number of biomolecules and pathways, including microRNAs. MicroRNAs can be carri…

Encapsulated microRNAs (i.e., miRNAs within the extracellular vesicles, i.e., EV-miRNAs) have been detected in follicular fluid in both animal and human studies and different profiles have been associated with IVF cycle characteristics. How…

Phthalates are a class of chemicals found in a large variety of consumer products. Available experimental and limited human data show adverse effects of some phthalates on ovarian function, which has raised concerns regarding potential effe…

ObjectiveTo study whether maternal intake of beverage type affects IVF outcomes.DesignA prospective study.SettingTertiary, university-affiliated center.Patient(s)Three hundred forty women undergoing IVF from 2014 through 2016 for infertilit…

Study questionDoes bisphenol-A (BPA) affect gene expression in human membrana granulosa cells (MGC)?Summary answerIn vitro, short exposure to supra-physiological concentrations of BPA alters human MGC gene expression.What is known alreadyEx…

PurposeThe purpose of this study is to determine the profile of extracellular microRNAs (exmiRNAs) in follicular fluid (FF) and explore their association with fertilization potential and embryo quality.MethodsWe collected FF from single fol…