Liu X

The Body Roundness Index (BRI) is an innovative anthropometric measure reflecting body shape and obesity, increasingly recognized as a potential predictor of infertility, warranting further exploration. This research employed a cross-sectio…

Intrahepatic cholestasis of pregnancy (ICP) is associated with an increased risk of adverse fetal outcomes, including fetal morbidity and mortality. It is a complex liver disorder influenced by genetic interactions, estrogen levels, and env…

PURPOSE: To investigate and compare the clinical characteristics and risk factors between intrinsic and extrinsic adenomyosis (AM), as well as the differences in their perioperative management and findings in the two subtypes. METHODS: Thi…

Oxidative stress plays a central role in reproductive disorders, with food bioactive compounds offering therapeutic potential through their antioxidant properties. This review examines antioxidant active ingredients from plant-based foods a…

BACKGROUND: Endosalpingiosis, a rare benign condition characterized by ectopic fallopian tube-like epithelium, often coexists with endometriosis. This case report presents a unique instance of florid cystic endosalpingiosis confined to the …

ImportanceHormonal contraceptive (HC) use is associated with depression. It is, however, unknown whether this is also true in the postpartum period when women have a heightened depression risk and are routinely offered HC treatment.Objectiv…

OBJECTIVE: Endometriosis (EMs) is a chronic inflammatory disease characterized by the presence of endometrial tissue in the non-uterine cavity, resulting in dysmenorrhea, pelvic pain, and infertility. Epidemiologic data have suggested the c…

BACKGROUND: To evaluate maternal and perinatal outcomes in women with different adenomyosis phenotypes and to assess the impact of placental attachment site in patients with intrinsic adenomyosis. METHODS: This retrospective cohort study a…

BackgroundEndometrial cancer represents a significant health challenge, with rising incidence and complex prognostic challenges. This study aimed to develop a robust predictive model integrating programmed cell death-related genes and advan…

STUDY QUESTION: Do all ectopic endometrial lesions (endometriosis and adenomyosis) universally have activated estrogen signaling? SUMMARY ANSWER: Estrogen signaling diminishes concordantly with increased fibrosis in ectopic endometrium, wi…

The purpose of this study was to investigate the anti-inflammatory effects of Perilla Seed Extract (PSE) and its active ingredient on Inflammatory Bowel Disease (IBD) in vitro and in vivo. Thirty-two C57/BL mice were randomly divided into f…

Natural products, recognized for their potential in disease prevention and treatment, have been integrated with advanced nano-delivery systems to create natural product-based nanomedicines, offering innovative approaches for various disease…

RESEARCH QUESTION: What role, if any, does the extent of lesional fibrosis play in impaired glycolysis leading to adenomyosis-associated heavy menstrual bleeding (ADM-HMB)? DESIGN: Forty-eight patients with ADM-HMB were recruited, among th…

In the field of genetic breeding, primordial germ cells (PGCs) have become essential cells for gene editing and genetic improvement due to their unique developmental potential and genetic characteristics. However, the low proliferation effi…

BackgroundPhthalate esters (PAEs) are a class of synthetic compounds that are extensively utilized in a range of consumer products, and they significantly affect both environmental conditions and human reproductive health. Especially, many …

Congenital cervical and vaginal atresia in the presence of a functioning endometrium is an extremely rare disease. Cervicovaginal reconstruction preserves fertility for these patients. We present the case of a 20-year-old patient who had ce…

RESEARCH QUESTION: Do any factors in patients with symptomatic adenomyosis contribute to the greater alleviation of dysmenorrhoea and heavy menstrual bleeding (HMB) after treatment with dienogest, and what are the risk factors, if any, for …

This study aims to investigate the effect and mechanism of resveratrol (RES) on lipopolysaccharide (LPS)-induced injury in goat granulosa cells (GCs). First, the appropriate time and concentration were screened for LPS (4 μg/mL, 12 h), RES …

OBJECTIVES: Adenomyosis (AM) is a chronic disorder that significantly impacts women's health and quality of life worldwide, particularly by causing progressive impairment in fertility. This study aimed to summarize and visualize the literat…

BackgroundMultimorbidity substantially increases health and economic burdens, and reduces productivity in working-age individuals. We conducted a study using data from 393,170 working-age inpatients (18-59 years) in Shaanxi, China, collecte…

Endometriosis (EMs) is a gynecological disorder characterized by chronic inflammation and an aberrant immune microenvironment. In this study, we integrated the GSE6364 dataset from the GEO database to identify differentially expressed genes…

BackgroundThe comorbidity of rheumatoid arthritis (RA), a chronic autoimmune disease, with cervical cancer has garnered a lot of attention. Cervical cancer is much more common in RA patients than in the general population, which may be caus…

Reproductive longevity is essential for female fertility and healthy aging; however, the role of stress response, especially stress granule accumulation, in ovarian aging remains elusive and interventions are lacking. Here, we identified de…

Endometriosis is characterized by aberrant epigenetic regulation, and our study reveals that both Ubiquitin Specific Protease 7 (USP7) and DNA methyltransferase 1 (DNMT1) are significantly overexpressed in endometriosis tissues. Functional …