Chen Chen — Endo Lab

other 2025

GRB2 regulation of essential signaling pathways in the endometrium is critical for implantation and decidualization

Nature communications ·doi:10.1038/s41467-025-57173-2

Over 75% of failed pregnancies involve implantation defects. Growth factor receptor-bound protein 2 (GRB2) is an adaptor protein involved in signal transduction and cell communication. Here we show that the expression of GRB2 protein is low…

other 2025

Hysteroscopic suture fixation for levonorgestrel-releasing intrauterine system in adenomyosis feasibility and therapeutic outcomes

Scientific reports ·doi:10.1038/s41598-025-22880-9

Levonorgestrel intrauterine-releasing system (LNG-IUS), an intrauterine device, is recommended for patients with adenomyosis; however, it often shows poor outcomes in these patients because of their large uterine size. This prospective stud…

review 2025

Targeting angiogenesis: Effects and mechanisms of action of ginsenosides

Phytomedicine : international journal of phytotherapy and phytopharmacology ·doi:10.1016/j.phymed.2025.157353

BACKGROUND: Angiogenesis is a key link in a variety of physiological and pathological processes and plays a crucial role in tissue repair, tumor growth and ischemic diseases. Ginsenosides, as the main active component of ginseng, have a uni…

article 2024

Identification and verification of diagnostic biomarkers for deep infiltrating endometriosis based on machine learning algorithms

Journal of biological engineering ·doi:10.1186/s13036-024-00466-9

This study addresses the challenges in the early diagnosis of deep infiltrating endometriosis (DIE) by exploring the potential role of the deubiquitinating enzyme USP14. By analyzing the GSE141549 dataset from the Gene Expression Omnibus (G…

2022

Detection of ovarian cancer via the spectral fingerprinting of quantum-defect-modified carbon nanotubes in serum by machine learning.

Nature biomedical engineering ·doi:10.1038/s41551-022-00860-y

Serum biomarkers are often insufficiently sensitive or specific to facilitate cancer screening or diagnostic testing. In ovarian cancer, the few established serum biomarkers are highly specific, yet insufficiently sensitive to detect early-…

2022

Does the cell number of 0PN embryos on day 3 affect pregnancy and neonatal outcomes following single blastocyst transfer?

BMC pregnancy and childbirth ·doi:10.1186/s12884-022-04492-7

Background0PN zygotes have a low cleavage rate, and the clinical outcomes of cleavage-stage embryo transfers are unsatisfactory. Blastocyst culturing is used to screen 0PN embryos, but whether the cell number of 0PN embryos on day 3 affects…

2021

Effectiveness of progesterone-primed ovarian stimulation in assisted reproductive technology: a systematic review and meta-analysis.

Archives of gynecology and obstetrics ·doi:10.1007/s00404-020-05939-y

PurposeProgestin-primed ovarian stimulation (PPOS) is a new ovarian stimulation protocol that has been used over the last decade to enhance reproductive function. The purpose of this study is to evaluate whether PPOS is as effective as conv…

other 2017

The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases

Nature communications ·doi:10.1038/s41467-017-00901-0

Reports on bacteria detected in maternal fluids during pregnancy are typically associated with adverse consequences, and whether the female reproductive tract harbours distinct microbial communities beyond the vagina has been a matter of de…

other 2014

The disturbance of TH17-Treg cell balance in adenomyosis

Fertility and sterility ·doi:10.1016/j.fertnstert.2013.10.050

OBJECTIVE: To investigate the balance between regulatory T cells (Treg) and T-helper 17 cells (T(H)17) in peripheral blood and uteri of women with adenomyosis (AM), and to evaluate their potential correlation with dysmenorrhea and CA-125 le…

article 2009

PDE8A Genetic Variation Is Not Associated with Polycystic Ovary Syndrome.

·doi:10.1093/biolreprod/81.s1.364

Polycystic ovary syndrome (PCOS) is characterized by excessive theca cell androgen secretion, dependent upon LH, which acts through the intermediacy of adenosine 3', 5'-cyclic monophosphate (cAMP). cAMP signaling pathways are controlled thr…

2009

Pyrimidine-2, 4-dione derivatives as gonadotropin-releasing hormone receptor antagonists