Debabrata Chakravarti

No ORCID on file · 3 papers in corpus · active 2020-2023

Study types

  • article 1
  • preprint 1
  • review 1

Condition tags

  • endometriosis 1
  • infertility 1
  • adenomyosis 1
review 2023
Endometriosis and adenomyosis: shared pathophysiology
Fertility and sterility ·doi:10.1016/j.fertnstert.2023.03.006

Endometriosis and adenomyosis are closely related disorders. Their pathophysiologies are extremely similar. Both tissues originate from the eutopically located intracavitary endometrium. Oligoclones of endometrial glandular epithelial cells…

article 2023
MED12 mutation activates the tryptophan/kynurenine/AHR pathway to promote growth of uterine leiomyomas
·doi:10.1172/jci.insight.171305

Uterine leiomyomas cause heavy menstrual bleeding, anemia, and pregnancy loss in millions of women worldwide. Driver mutations in the transcriptional mediator complex subunit 12 (MED12) gene in uterine myometrial cells initiate 70% of leiom…

preprint 2020
Single Cell atlas of uterine myometrium and leiomyomas reveals diverse and novel cell types of non-monoclonal origin
·doi:10.1101/2020.12.21.402313

Abstract Uterine leiomyomas are the most common tumors of the female reproductive tract with significant morbidity that includes excessive bleeding, infertility and pregnancy complications. The origin and cellular composition of leiomyomas …