Azna Zuberi

ORCID: 0000-0002-3970-4641 · 3 papers in corpus
article 2025
Stearoyl–coenzyme A desaturase enhances cell survival in human uterine leiomyoma
·doi:10.1016/j.xfss.2025.01.005

OBJECTIVE: Stearoyl-CoA desaturase (SCD1) is an enzyme that catalyzes the conversion of saturated delta-9 fatty acids to monounsaturated fatty acids. SCD1 is highly expressed in various cancers and facilitates cancer cell survival, tumor gr…

article 2025
Therapeutic targeting of the tryptophan-kynurenine-aryl hydrocarbon receptor pathway with apigenin in MED12-mutant leiomyoma cells
·doi:10.1038/s41417-025-00881-0

Approximately 77.4% of uterine leiomyomas carry MED12 gene mutations (mut-MED12), which are specifically associated with strikingly upregulated expression and activity of the tryptophan 2,3-dioxygenase (TDO2) enzyme, leading to increased co…

article 2023
MED12 mutation activates the tryptophan/kynurenine/AHR pathway to promote growth of uterine leiomyomas
·doi:10.1172/jci.insight.171305

Uterine leiomyomas cause heavy menstrual bleeding, anemia, and pregnancy loss in millions of women worldwide. Driver mutations in the transcriptional mediator complex subunit 12 (MED12) gene in uterine myometrial cells initiate 70% of leiom…