John S. Coon

ORCID: 0000-0003-0521-0157 · 7 papers in corpus · active 2014-2025

Study types

  • article 6
  • other 1

Condition tags

  • endometriosis 3
  • mesh:D004715 2
article 2025
Stearoyl–coenzyme A desaturase enhances cell survival in human uterine leiomyoma
·doi:10.1016/j.xfss.2025.01.005

OBJECTIVE: Stearoyl-CoA desaturase (SCD1) is an enzyme that catalyzes the conversion of saturated delta-9 fatty acids to monounsaturated fatty acids. SCD1 is highly expressed in various cancers and facilitates cancer cell survival, tumor gr…

article 2025
Therapeutic targeting of the tryptophan-kynurenine-aryl hydrocarbon receptor pathway with apigenin in MED12-mutant leiomyoma cells
·doi:10.1038/s41417-025-00881-0
article 2023
MED12 mutation activates the tryptophan/kynurenine/AHR pathway to promote growth of uterine leiomyomas
·doi:10.1172/jci.insight.171305

Uterine leiomyomas cause heavy menstrual bleeding, anemia, and pregnancy loss in millions of women worldwide. Driver mutations in the transcriptional mediator complex subunit 12 (MED12) gene in uterine myometrial cells initiate 70% of leiom…

article 2022
Tryptophan 2,3-Dioxygenase-2 in Uterine Leiomyoma: Dysregulation by MED12 Mutation Status
·doi:10.1007/s43032-022-00852-y

Uterine leiomyomas (fibroids) are common benign tumors in women. The tryptophan metabolism through the kynurenine pathway plays important roles in tumorigenesis in general. Leiomyomas expressing mutated mediator complex subunit 12 (mut-MED1…

article 2020
Genome-wide estrogen receptor-α binding and action in human endometrial stromal cells
F&S science ·doi:10.1016/j.xfss.2020.06.002

OBJECTIVE: To investigate the gene targets of estradiol (E2)-estrogen receptor-α (ESR1) in human endometrial stromal cells. DESIGN: Basic science. SETTING: University research center. PATIENT(S): Premenopausal women with or without endometr…

other 2016
Estrogen receptor β regulates endometriotic cell survival through serum and glucocorticoid-regulated kinase activation
Fertility and sterility ·doi:10.1016/j.fertnstert.2016.01.012

OBJECTIVE: To determine the expression and biological roles of serum and glucocorticoid-regulated kinase (SGK1) in tissues and cells from patients with endometriosis and from healthy control subjects. DESIGN: Case-control. SETTING: Univer…

article 2014
ERβ- and Prostaglandin E2-Regulated Pathways Integrate Cell Proliferation via Ras-like and Estrogen-Regulated Growth Inhibitor in Endometriosis
Molecular endocrinology (Baltimore, Md.) ·doi:10.1210/me.2013-1421

In endometriosis, stromal and epithelial cells from the endometrium form extrauterine lesions and persist in response to estrogen (E2) and prostaglandin E2 (PGE2). Stromal cells produce excessive quantities of estrogen and PGE2 in a feed-fo…