Lu X

Recurrent implantation failure (RIF) remains a major challenge in assisted reproductive technology, and the molecular mechanisms underlying endometrial receptivity are incompletely understood. This study aimed to comprehensively characteriz…

INTRODUCTION: Endometriosis, a chronic gynecological disorder, significantly impacts fertility and quality of life. Identifying effective therapeutic targets is critical for their management. OBJECTIVES: The objective of this study was to …

Early detection of asymptomatic ovarian cancer (asym-OC) remains a critical challenge, the failure of which underlies its high mortality. Performing serum peptidomic profiling of 843 participants in the cohort SOCFCP, we distill 1,081 initi…

ABSTRACT: The endometrium is the primary site of embryo implantation. Cellular senescence within the endometrium can be broadly categorised into normal cyclical senescence and pathological excessive senescence. Normal cyclical senescence oc…

OBJECTIVE: This study aims to evaluate and compare the clinical effectiveness of endovascular reintervention vs conservative medical therapy in patients with persistent or recurrent venous-origin chronic pelvic pain (CPP) after initial endo…

PURPOSE: This study utilized 1990-2019 data from the Global Burden of Disease (GBD) 2019 study to comprehensively evaluate global and regional temporal trends of endometriosis burden. PATIENTS AND METHODS: Age-standardized incidence rates …

Xiaoyan Lu, Shanshan NiDepartment of Obstetrics, Beilun People’s Hospital, Ningbo, Zhejiang, 31580, People’s Republic of ChinaCorrespondence: Shanshan Ni, Department of Obstetrics, Beilun People’s Hospital, No. 1288 East Lushan Road, Ningbo…

Abstract Background The microbiome of the female reproductive system has been extensively studied; however, the correlation between uterine microbial alterations and endometriosis remains unclear. Methods Endometrial and lesion tissues wer…

BACKGROUND: In assisted reproductive technology, preventing premature ovulation is crucial for achieving successful pregnancy outcomes. The traditional GnRH antagonist protocol is commonly used to suppress the luteinizing hormone (LH) surge…

BACKGROUND: Insulin resistance (IR) is a common pathophysiologic feature in patients with polycystic ovary syndrome (PCOS). However, there have been no studies investigating the association of IR surrogates with pregnancy outcomes in women …

The diverse and dynamic population of microorganisms present in the gut microbiota may affect host health. There are evidences to support the role of gut microbiota as a key player in reproductive development. Unfortunately, the relationshi…

Sleep disorders, particularly obstructive sleep apnea (OSA), circadian disruption, and insomnia, are increasingly recognized as contributors to the onset and progression of gynecologic cancers. This review explores the bidirectional interac…

OBJECTIVE: To explore the role of endometrial defects in the pathogenesis of abnormal uterine bleeding (AUB). DESIGN: Retrospective case-control study. SETTING: Two tertiary centres. POPULATION OR SAMPLE: We included 155 patients with ca…

Endometriosis (EMS) is a chronic disease characterized by unclear etiology, influenced by various genetic and environmental factors, with no definitive biomarkers available for early screening. Recent studies suggest that the abdominal micr…

PURPOSE: To analyze prognostic factors and survival outcomes in patients with synchronous endometrial and ovarian cancer (SEOC) to guide clinical management. METHODS: We conducted a retrospective cohort study of patients diagnosed with SEO…

BACKGROUND: To overcome the challenge of psychotherapist scarcity in applying pain psychotherapy in clinical practice, we developed a virtual reality (VR) program delivering weeks of pain psychotherapy without psychotherapists, with a focus…

In the surgical treatment of deep infiltrating endometriosis, the completeness of lesion removal is crucial for the success of the procedure. Consequently, an array of auxiliary surgical methods are continuously being refined to improve the…

BACKGROUND: Uterine rupture in pregnant women can lead to serious adverse outcomes. This study aimed to explore the clinical characteristics, treatment, and prognosis of patients with complete uterine rupture. METHODS: Data from 33 cases o…

BACKGROUND: The basal luteinizing hormone (LH) and the prior LH to follicle-stimulating hormone (FSH) ratio (LH/FSH) in polycystic ovarian syndrome (PCOS) are generally higher than those in non-PCOS patients and the general population. The …

Abstract Exosomes play significant roles in immune responses, neurogenesis, and angiogenesis, directly impacting the progression and symptomatic manifestations of endometriosis. This study aimed to investigate the role of exosomal miR-146a…

BACKGROUND: Semaphorin 3A (Sema3A) is a member of neural guidance factor family well-known for inducing the collapse of nerve cell growth cone and regulating nerve redistribution. It also has been characterized as an immunoregulatory and tu…

OBJECTIVE: Recurrent pregnancy loss (RPL) patients have higher absolute numbers of decidual natural killer (dNK) cells with elevated intracellular IFN-γ levels leading to a pro-inflammatory cytokine milieu, which contributes to RPL pathogen…

Oxidative phosphorylation is becoming increasingly important in the induction and development of endometriosis. Recently, it has been reported that ring finger protein 43 (RNF43) is involved in the process of oxidative phosphorylation, but …

OBJECTIVES: The annual prevalence of chronic rhinosinusitis (CRS) is increasing, and the lack of effective treatments imposes a substantial burden on both patients and society. The formation of nasal polyps in patients with CRS is closely r…

The adverse effect of ambient PM2.5 exposure on very early pregnancy (VEP) remains controversial among epidemiological studies but is supported by toxicological evidence. We adopted a multicenter retrospective cohort of 141,040 cycles to ev…