Development and validation of a serum peptidomic signature for early detection of asymptomatic ovarian cancer: A multi-center prospective study.

Li Z, Zhang H, Bi R, Zhang Y, Shi W, Yang H, Cheng S, Wang C, Zhao Y, Li Y, Lu X, Chen X, Zhou Y, Dong B, Xue R, Wang Y
Cell reports. Medicine · 2026 · doi:10.1016/j.xcrm.2026.103014 · PMID:42664958 · PMC13589509
OA: gold
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Abstract

Early detection of asymptomatic ovarian cancer (asym-OC) remains a critical challenge, the failure of which underlies its high mortality. Performing serum peptidomic profiling of 843 participants in the cohort SOCFCP, we distill 1,081 initial features into a 7-marker panel for asym-OC detection via a biology-informed machine-learning (ML)-based feature selection strategy. Three markers significantly revert toward non-OC levels after surgery. Integrating the panel with age, CA125, and HE4, we develop and externally validate (n = 159) a LightGBM model, ProMS+. For early-stage OC detection, ProMS+ shows a specificity of 92.6% at 95.0% sensitivity, outperforming CA125 (44.7%), HE4 (11.2%), and Risk of Ovarian Malignancy Algorithm (ROMA) (24.0%), with an area under the curve (AUC) of 0.993. In a simulated high-risk population (n = 100,000; OC prevalence = 1%), ProMS+ yields a high AUC (0.983) and a higher positive predictive value than CA125, HE4, and Age + CA125 + HE4 combined model (0.201 vs. 0.027, 0.090, and 0.064). ProMS+ offers a promising, non-invasive, and interpretable approach for the early detection of asym-OC.

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organisms 4
noordeloos 2009062 human noordeloos 2009062 human
chemicals 61
peptide chloride chloride toluene ammonium hydroxide acetonitrile trifluoroacetic acid 2-[(carboxymethyl)(methyl)amino]-5-methoxybenzoic acid bromide water toluene ammonium hydroxide water argon water toluene toluene argon toluene acetonitrile trifluoroacetic acid trifluoroacetic acid acetonitrile acid acetonitrile betavulgaroside ii peptide peptide peptide peptide peptide peptide lipid hydroxyl sn-monothiophosphatidylcholine phosphocholine lipid angiotensin ii lipid lipid lipid peptide lipid peptide peptide lipid lipid triglyceride cholesterol lipoprotein nanoparticle nanostructure glycoprotein lipid lipid lysophosphatidylcholine lipid peptide peptide +1 more

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