Gupta S

AbstractChronic pancreatitis (CP) is a progressive inflammatory disorder of the pancreas characterized by irreversible fibrosis and intraductal calculi, leading to recurrent abdominal pain and functional impairment. Here, we present the cas…

IntroductionCircadian rhythm disruption caused by shift work, nutritional imbalance, and the stresses of modern life can alter hormone secretion, lead to menstrual irregularities, impair follicle development, and contribute to ovarian hypop…

This case report describes a rare presentation of primary periumbilical endometriosis, also known as Villar's nodule, highlighting the diagnostic difficulties and the importance of maintaining clinical suspicion. A 37‑year‑old woman present…

Endometriosis and polycystic ovary syndrome (PCOS) are common, multifactorial gynecological disorders shaped by endocrine imbalance, immune dysfunction, metabolic disruption, genetic susceptibility, and environmental exposures. Despite thei…

OBJECTIVE: To address the reporting of minimal clinically important differences (MCIDs) in the published literature and investigate the utility of absolute and relative differences when defining this parameter. DESIGN: Expert opinion. SUB…

BackgroundOvarian mass is not an uncommon imaging finding in women of all age groups. Hence, frozen section plays a very important role in determining the nature of the mass and, thus, deciding the appropriate surgical procedure. In the pre…

Enhancer of Zeste Homolog 2 (EZH2) is a key epigenetic regulator known for its role in global gene silencing and is involved in a variety of cellular processes, including cell survival, proliferation, invasion, and self-renewal. As a core c…

In women with endometriosis, monocyte chemoattractant protein 1 (MCP-1) or chemokine (C-C motif) ligand 2 (CCL2) is elevated in serum, peritoneal fluid, and endometriotic lesions, though its exact role in endometriosis is still unknown. The…

Endometriosis, an endocrine disorder in reproductive-aged women with an occurrence of ∼10 %, gives rise to inflammation, pelvic pain, menstrual irregularity, infertility, etc. One study demonstrated the elevated plasma level of PARP during …

Ovarian leiomyomas are rare benign smooth muscle tumors, accounting for <1% of all ovarian neoplasms. While most commonly found in premenopausal women, their occurrence in postmenopausal women is rare and often raises concerns about maligna…

OBJECTIVE: To provide a framework for conducting rigorous nonrandomized studies of interventions in fertility treatment research, addressing their role as complements to randomized controlled trials (RCTs) in evaluating treatment outcomes. …

BackgroundIOTA proposed Simple Ultrasound Rules in 2009 for preoperative diagnosis of ovarian masses based on ultrasound only. It is an accurate, simple and inexpensive method. RMI, however, requires CA125 level. While RMI-4 is the latest, …

BackgroundHeavy menstrual bleeding (HMB) is common, and 20-30% of patients presenting with HMB are diagnosed with an inherited bleeding disorder (IBD). Despite the frequent association of HMB with bleeding disorders, specific learning objec…

Abstract Background With the increasing representation of women in sports, addressing menstrual health issues, specifically menstrual dysfunctions (MDs), has gained significance. This study aimed to gain a comprehensive understanding of th…

AimThis study aimed to determine the prevalence of microbiologically confirmed female genital tuberculosis (FGTB) infection in patients attending a tertiary care hospital in North India.Materials and methodsA total of 623 endometrial biopsy…

Gynecological cancer, the most common form of cancers in women worldwide, initiates in the reproductive organs of females. More often, the common treatment measures, i.e. surgery, radiation, and medical oncology are found to be unsuccessful…

OBJECTIVES: The objective is to discover the etiopathogenesis of benign lower ureteric stricture in Eastern India and compare the outcome of open versus laparoscopic ureteroneocystostomy. MATERIALS AND METHODS: Retrospectively 52 patients …

Inflammation is the defense mechanism of the immune system against harmful stimuli such as pathogens, toxic compounds, damaged cells, radiation, etc., and is characterized by tissue redness, swelling, heat generation, pain, and loss of tiss…

Low-grade serous carcinoma (LGSC) is a rare histologic subtype of ovarian cancer. We present detailed management of 15 cases of advanced LGSC from a tertiary cancer center of India. Fifteen cases of advanced LGSC who underwent cytoreductive…

We present a report of two adult females who presented to the surgery clinic at different time frames in our hospital with a swelling in the inguinal region. The swelling was painful for one of our patients. The first patient was evaluated …

PurposeIn an oncological set up the role of frozen section biopsy is undeniable. They serve as an important tool for surgeon's intraoperative decision making but the diagnostic reliability of intraoperative frozen section may vary from inst…

Endometriosis is a chronic gynecological disease in women of childbearing age, which leads to infertility with risk of endometrial and ovarian cancer. The pathogenesis of endometriosis is poorly understood, and cure/treatment for it is not …

The manuscript uses the previously published literature and highlights the benefits of active-matrix metalloproteinase (aMMP)-8 chairside/point-of-care (PoC) diagnostic tools as adjunctive measures in oral and systemic diseases. Previous st…

Cervical cancer is one of the top malignancies in women around the globe, which still holds its place despite being preventable at early stages. Gynecological conditions, even maladies like cervical cancer, still experience scrutiny from so…