Zhang D

This study aims to assess associations of dyslipidemia with in vitro fertilization/intracytoplasmic sperm injection outcomes in women undergoing their first ovarian stimulation and whether age, body mass index, or lipid levels modify these …

Conventional in vitro fertilization (IVF) outcome prediction is limited by static, single-endpoint analyses. We aimed to overcome this by using a multistate model to dissect the stage-specific and, crucially, the non-linear influence of end…

Our study aimed to explore the mechanisms underlying abnormal angiogenesis in adenomyosis (AM). Endometria of internal adenomyosis (AM-in) and external adenomyosis (AM-ex) were collected for single-cell RNA-sequencing. Cells showing consist…

Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study. Figure S1. Ultrasound images of the pelvis. (A) The uterus is enlarged, measuring approximately 59 × 57 × 60 mm, with heterog…

Preeclampsia (PE) is a major cause of maternal and perinatal morbidity. Because abnormal fat distribution is closely related to metabolic dysfunction, vascular injury, and hypertensive disorders during pregnancy, clarifying its genetic rela…

Lymph node metastasis (LNM) is a key factor in the recurrence and progression of papillary thyroid carcinoma (PTC). Phosphodiesterase 4C (PDE4C) serves as a crucial regulator in cancer development and metastasis, its functional role and mec…

Endometriosis, a chronic disease that affects about 10% of women of reproductive age, is characterized by severe pain and growth of endometrium-like tissues outside the uteri. Although several theories have been advanced for the cause of en…

BACKGROUND: Adenomyosis (AM) is a common gynecological disorder in reproductive-age women, with impaired endometrial receptivity as a key contributor to infertility. However, a comprehensive single-cell atlas of the eutopic endometrium duri…

Endometriosis is a common gynecological disease associated with pelvic pain and infertility. Despite several existing theories, the etiology and molecular mechanisms of endometriosis remain to be investigated. Here we report that transcript…

The fibrosis mechanism in endometriosis is not elucidated. We investigated the role of eosinophil in fibrosis of endometriosis. The endometriotic stromal cells (ESCs) and endometrial epithelial cells (EECs) were subjected to in vitro experi…

BACKGROUND: The C-reactive protein-triglyceride glucose index (CTI) is a promising new marker for evaluating the severity of inflammation. Endometriosis (EM) is a prevalent chronic inflammatory condition influenced by estrogen, primarily af…

BackgroundCervical intraepithelial neoplasia grade 2 (CIN2) is one of the precursor stages before cervical lesions develop into cervical cancer. The spontaneous development of CIN2 is ambiguous. One part of CIN2 lesions will progress to cer…

PROBLEM: The relationship between abortion and endometriosis (EMS) has been inconsistent in previous observational studies and remains controversial. We intended to examine the causal relationship between abortion and EMS. METHODS OF STUDY…

Gynecological cancers, including cervical, ovarian, and endometrial malignancies, remain a significant global health burden, exacerbated by disparities in access to preventive measures such as HPV vaccination and routine screening. The cGAS…

Supplemental Figure 1. Forest plots demonstrating pool sensitivity and specificity of transvaginal ultrasound in the diagnosis of ureteral endometriosis. Supplemental Figure 2. Summary receiver-operating characteristic curves showing perfor…

IN BRIEF: There is no ideal animal model of adenomyosis, which reflects the imperfect understanding of complex human pathogenesis. In this study, we successfully induced adenomyosis in a mouse model via sharp-blunt trauma, which more closel…

Endometriosis is a common gynaecological disease and there is no reliable non-invasive biomarker for its unknown pathogenesis. TRF is differentially expressed in a variety of cancers and is a new non-invasive biomarker. The aim of this stud…

Aging and neurodegenerative diseases are characterized by cognitive decline, impaired neuroplasticity, and epigenetic dysregulation. Curcumin, a bioactive polyphenol derived from Curcuma longa, has gained significant attention for its neuro…

BackgroundGnRH-a is commonly used in the luteal phase for pituitary down-regulation during in-vitro fertilization (IVF). There is an ineluctable risk of spontaneous pregnancy for infertile couples who lack the use of contraception during th…

BackgroundFew studies have analyzed the endometrial preparation protocols for frozen-thawed embryo transfer (FET) in patients at high risk of ovarian hyperstimulation syndrome (OHSS). This study aimed to investigate the optimal protocol for…

ObjectiveThis study aimed to examine the impact of laser-assisted hatching (LAH) on the physical, metabolic, cognitive and behavioural profiles of singletons conceived through frozen-thawed embryo transfer (FET) at the preschool age.DesignA…

BackgroundElevated systemic oxidative stress contributes to endometrial damage. Individuals with obstructive sleep apnea (OSA) exhibit significantly elevated oxidative stress; however, the potential role of oxidative stress in OSA-induced e…

Endometriosis has been increasingly associated with the aberrant regulation of non-coding RNAs (ncRNAs), particularly long non-coding RNAs (lncRNAs) and microRNAs (miRNAs). Despite the growing recognition of their biological significance, t…