David Westergaard

No ORCID on file · 14 papers in corpus · active 2014-2026

Study types

  • other 3
  • meta-analysis 2
  • article 1

Condition tags

  • endometriosis 5
  • infertility 4
  • adenomyosis 2
2026
·doi:10.64898/2026.06.18.26355987

Purpose Endometriosis is associated with pain, cardiometabolic, psychiatric, and immune comorbidities. We tested whether the genetic liability captured by an endometriosis polygenic risk score (PRS) extends to these comorbidities through s…

meta-analysis 2025
Nature genetics ·doi:10.1038/s41588-025-02156-8

Genome-wide association studies (GWASs) may help inform the etiology of infertility. Here, we perform GWAS meta-analyses across seven cohorts in up to 42,629 cases and 740,619 controls and identify 25 genetic risk loci for male and female i…

2025
Nature medicine ·doi:10.1038/s41591-025-03621-x

Intracytoplasmic sperm injection (ICSI) and conventional in vitro fertilization (c-IVF) are widely used fertilization techniques in assisted reproduction, but their relative effectiveness in patients without severe male factor infertility r…

article 2025
·doi:10.1093/humrep/deaf097.218

Abstract Study question • Does adenomyosis increase risk of euploid pregnancy loss (PL)? • Is there a correlation of euploid PL and direct and/or indirect features of adenomyosis? Summary answer No increased risk of euploid PL was observed …

other 2024
medRxiv : the preprint server for health sciences ·doi:10.1101/2024.03.19.24304530

Genome-wide association studies (GWASs) may help inform treatments for infertility, whose causes remain unknown in many cases. Here we present GWAS meta-analyses across six cohorts for male and female infertility in up to 41,200 cases and 6…

2024
Nature genetics ·doi:10.1038/s41588-024-01839-y

Bleeding in early pregnancy and postpartum hemorrhage (PPH) bear substantial risks, with the former closely associated with pregnancy loss and the latter being the foremost cause of maternal death, underscoring the severe impact on maternal…

2024
BMC medicine ·doi:10.1186/s12916-024-03797-y

BackgroundPregnancy is a complex biological process and serious complications can arise when the delicate balance between the maternal and semi-allogeneic fetal immune systems is disrupted or challenged. Gestational diabetes mellitus (GDM),…

other 2023
Fertility and sterility ·doi:10.1016/j.fertnstert.2022.12.042

OBJECTIVE: To study whether endometriosis is associated with pregnancy loss and recurrent pregnancy loss (RPL). DESIGN: Nationwide historical cohort study with a nested case-control analysis. SETTING: National health registers. PATIENT(S…

2023
Nature genetics ·doi:10.1038/s41588-023-01343-9

The timing of parturition is crucial for neonatal survival and infant health. Yet, its genetic basis remains largely unresolved. We present a maternal genome-wide meta-analysis of gestational duration (n = 195,555), identifying 22 associate…

other 2023
Fertility and sterility ·doi:10.1016/j.fertnstert.2023.05.003
meta-analysis 2023
Nature genetics ·doi:10.1038/s41588-023-01323-z

Endometriosis is a common condition associated with debilitating pelvic pain and infertility. A genome-wide association study meta-analysis, including 60,674 cases and 701,926 controls of European and East Asian descent, identified 42 genom…

2020
Journal of the American Heart Association ·doi:10.1161/jaha.119.015069

Background It is unclear how recurrent pregnancy loss (RPL) impacts disease risk and whether there is a difference in risk between women with or without a live birth before RPL (primary versus secondary RPL). We investigated the disease ris…

2019
BMJ open ·doi:10.1136/bmjopen-2018-028401

PurposeTo establish a cohort that enables identification of genomic factors that influence human health and empower increased blood donor health and safe blood transfusions. Human health is complex and involves several factors, a major one …

2014
Journal of ovarian research ·doi:10.1186/s13048-014-0110-6

BackgroundCorona radiata cells (CRCs) refer to the fraction of cumulus cells just adjacent to the oocyte. The CRCs are closely connected to the oocyte throughout maturation and their gene expression profiles might reflect oocyte quality. Po…