Chen Q

Perioperative abstinent smokers experience heightened pain sensitivity and increased postoperative analgesic requirements, likely due to nicotine withdrawal-induced hyperalgesia. However, the underlying neural mechanisms in humans remain un…

OBJECTIVE: This study aims to propose a novel, reproducible transvaginal ultrasound (TVUS) measurement-anterior-posterior wall thickness of the uterine isthmus ratio (APTUIR)-and to construct a nomogram model integrating this parameter with…

BACKGROUND: Patients undergoing assisted reproductive technology (ART) frequently manifest sleep disturbances and psychological morbidity. This study examined associations between cerebral activation patterns, sleep quality, and psychologic…

BACKGROUND: Endometriosis-associated ovarian cancer is a distinct form of epithelial ovarian cancer that arises from the malignant transformation of benign endometriotic lesions. While epithelial-mesenchymal transition is acknowledged as a …

Hydrogels are highly hydrated three-dimensional polymeric network materials that have attracted considerable attention in medical and biomedical fields owing to their favorable chemical modifiability, physical tunability, biocompatibility, …

BACKGROUND: Ovarian endometriosis(OEM) is a highly prevalent condition that significantly affects women’s health. Tissue-derived extracellular vesicles(Ti-EVs) contain multiple molecules that maintain intercellular communication. They parti…

BACKGROUND: Endometriosis is a prevalent benign condition among women of reproductive age. While the overall rate of endometriosis-associated malignancy is low, the risk of malignant transformation increases significantly in postmenopausal …

The pathogenesis of endometriosis (EM) remains intricate and multifactorial. This study aimed to investigate the biological functions of microRNA-769-5p (miR-769-5p) in an in vitro model of EM. Serum was obtained from 120 EM patients and 10…

Endometriosis is a chronic systemic disease affecting ~10% of women, yet its genetic basis and molecular mechanisms remain poorly understood. Hence, here we conducted a genome-wide association study of endometriosis and adenomyosis in ~1.4 …

PurposeThis study aimed to develop a predictive model for diminished ovarian reserve (DOR) in reproductive-aged women with Hashimoto's thyroiditis (HT) by integrating transvaginal three-dimensional ultrasound and clinical multimodal data, t…

This narrative review synthesizes the latest advances in nano-diagnostic and therapeutic reagents for acute pancreatitis (AP), based on peer-reviewed experimental and preclinical studies published in recent years. AP endangers life through …

Gastric metastasis from breast cancer (GMBC) is a rare but diagnostically challenging condition, whose clinical and imaging features often mimic primary gastric cancer or treatment-related adverse effects. This study integrates a detailed c…

Endometriosis (EM) is a prevalent gynecological disorder linked to pelvic pain, menstrual disturbances, and infertility. Despite its clinical burden, the molecular mechanisms underlying EM remain elusive, necessitating the discovery of nove…

BACKGROUND: Endometriosis (EMs) is an estrogen-dependent chronic inflammatory disease, and its pathogenesis remains unclear. Although the placenta is an organ with tumor-like characteristics, its development, including its invasive function…

Endometrioid carcinoma is one of the most prevalent malignant neoplasms in gynecology, in contrast to perivascular epithelioid cell tumor (PEComa), a rare stromal tumor, which is seldom encountered in the female genital system. The coexiste…

BackgroundInfertility affects many couples worldwide, and the accurate assessment of endometrial receptivity (ER) is critical. However, conventional ultrasound has limited predictive value. Multiparameter quantitative ultrasound is a promis…

BackgroundTo evaluate whether progesterone-induced changes in endometrial thickness (EMT) affect singleton infant outcomes during frozen-thawed embryo transfer (FET) cycles.MethodsThis retrospective study analyzed 6,331 singleton live birth…

BackgroundAbnormalities in ureteral motility often precede morphological changes, and early subtle lesions are easily overlooked, thereby increasing the risk of renal impairment. However, existing imaging assessments tend to focus on qualit…

INTRODUCTION: This study aimed to examine the impact of quercetin on a mouse model of endometriosis and elucidate its underlying mechanisms. METHODS: An endometriosis model was established using C57BL/6 mice, which were divided into three …

OBJECTIVE: The aim of this study was to investigate the effects of SEPT9 on proliferation, migration, and apoptosis in endometriotic stromal cells and to explore the underlying mechanisms. METHODS: Immunohistochemistry and western blotting…

BACKGROUND: Ovarian endometriosis (OEMs) is a primary cause of female infertility and is driven primarily by fibrosis, which disrupts the ovarian follicular microenvironment. Pirfenidone (PFD), an FDA-approved antifibrotic drug, holds promi…

Poly(lactic acid-lactic acid) (PLGA) has demonstrated significant application potential in tumor-targeted drug delivery systems due to its excellent biocompatibility, degradability, and multifunctionality for loading various therapeutic age…

BackgroundTraditional research on the female reproductive tract (FRT) microbiome has focused on the dominance of bacteria, particularly Lactobacillus, as a marker of health. This bacteriocentric paradigm, however, cannot fully explain clini…

Y-box binding protein 1 (YBX1) has been reported to play a role in human granulosa cell (GC) dysfunction by binding with long noncoding RNAs in patients with primary ovarian insufficiency (POI). 5-Methylcytosine (m5C) methylation is an abun…