Philippa T. K. Saunders (34887)

No ORCID on file · 7 papers in corpus · active 2015

Study types

  • other 4
  • dataset 3

Condition tags

  • endometriosis 7
other 2015
All TGF-β ligands are expressed in peritoneal fluid from women with and without endometriosis.
·doi:10.1371/journal.pone.0106773.g001

TGF-β1 was significantly increased in peritoneal fluid from women with endometriosis compared to women without. Levels of TGF-β2 do not change between women with and without endometriosis. TGF-β3 levels appear to increase in women with endo…

dataset 2015
Data S1 - The Peritoneum Is Both a Source and Target of TGF-β in Women with Endometriosis
·doi:10.1371/journal.pone.0106773.s001

The TGF-β signalling targets array (Quigen, Manchester UK) assays 84 TGF-β regulated genes involved in functional processes, including; differentiation, proliferation, migration, apoptosis and cell cycle control. We made three comparisons u…

other 2015
TGFB1 mRNA expression was significantly increased in the peritoneum adjacent to endometriosis lesions compared to peritoneum distal to lesions in women with endometriosis (B).
·doi:10.1371/journal.pone.0106773.g003

There was no signifianct difference in TGFB1 expression between women with and without endometriosis, nor was there a difference in expression between control and prone sites of peritoneum in women without endometriosis. There is no signifi…

dataset 2015
Table displays gene expression including fold change and p value of TGF-β signalling target genes in peritoneal biopsies from women with endometriosis at sites ajacent compared to sites distal to endometriosis lesions.
·doi:10.1371/journal.pone.0106773.t003

n = 6.Table displays gene expression including fold change and p value of TGF-β signalling target genes in peritoneal biopsies from women with endometriosis at sites ajacent compared to sites distal to endometriosis lesions.

dataset 2015
Table displays gene expression including fold change and p value of TGF-β signalling target genes in peritoneal biopsies from women with endometriosis compared to women without at sites prone and adjacent to endometriosis lesions.
·doi:10.1371/journal.pone.0106773.t002

n = 6.Table displays gene expression including fold change and p value of TGF-β signalling target genes in peritoneal biopsies from women with endometriosis compared to women without at sites prone and adjacent to endometriosis lesions.

other 2015
TGF-β1, TGF-βR1, TGF-βR2, and pSmad 2/3, are localized to the mesothelial cells of the peritoneum of women without endometriosis at contol sites and prone sites.
·doi:10.1371/journal.pone.0106773.g002

TGF-β1, TGF-βR1, TGF-βR2, and pSmad 2/3, are localized to the mesothelial cells of the peritoneum of with endometriosis at sites disteal and ajacent to endometriosis lesions. No staining was observed in the negative control sections. n = 8.

other 2015
Venn diagram displaying significant changes in gene expression of TGF-β signalling target in the 3 comparisons made between women with and without endometriosis.
·doi:10.1371/journal.pone.0106773.g004

Venn diagram displaying significant changes in gene expression of TGF-β signalling target in the 3 comparisons made between women with and without endometriosis.