TGFB1 mRNA expression was significantly increased in the peritoneum adjacent to endometriosis lesions compared to peritoneum distal to lesions in women with endometriosis (B).

Vicky J. Young (627900), Jeremy K. Brown (101879), Philippa T. K. Saunders (34887), W. Colin Duncan (209189), Andrew W. Horne (209218)
2015 · doi:10.1371/journal.pone.0106773.g003 · W6960727311
Other OA: green CC0
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by qwen3.7-flash, 2026-10-11 ⓘ

TGFB1 mRNA expression was significantly increased in the peritoneum adjacent to endometriosis lesions compared to distal sites, while TGFBR1, TGFBR2, and SMAD3 levels showed no significant changes.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by qwen3.7-flash, 2026-10-11 · read from full text ⓘ

This study investigated the role of transforming growth factor-beta 1 (TGF-β1) in the peritoneal environment of women with endometriosis. Researchers measured mRNA expression levels of TGFB1 and its signaling components, including TGFBR1, TGFBR2, and SMAD3, in peritoneal tissue samples collected from both lesion-adjacent and distant sites. The analysis revealed that TGFB1 mRNA expression was significantly elevated in peritoneum adjacent to endometriosis lesions compared to areas further away, indicating local upregulation near disease sites. However, no significant differences were found in overall TGFB1 expression between women with and without the condition, nor were there changes in the expression of other signaling molecules across all comparisons. This paper is centrally about endometriosis — specifically examining the local molecular environment and TGF-β signaling pathway activity within the peritoneal cavity surrounding endometriotic implants.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

There was no signifianct difference in TGFB1 expression between women with and without endometriosis, nor was there a difference in expression between control and prone sites of peritoneum in women without endometriosis. There is no significant change in mRNA expression for TGFBR1, TGFBR2 and SMAD3 in all comparisons made (A, C–L). n = 35 (*p<0.05).
Full text 616 characters · extracted from oa-doi-fallback · click to expand
The Peritoneum Is Both a Source and Target of TGF-β in Women with Endometriosis Figure 3 TGFB1 mRNA expression was significantly increased in the peritoneum adjacent to endometriosis lesions compared to peritoneum distal to lesions in women with endometriosis (B). There was no signifianct difference in TGFB1 expression between women with and without endometriosis, nor was there a difference in expression between control and prone sites of peritoneum in women without endometriosis. There is no significant change in mRNA expression for TGFBR1, TGFBR2 and SMAD3 in all comparisons made (A, C–L). n = 35 (*p<0.05).

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

Source provenance

openalex
last seen: 2026-05-11T08:54:20.463269+00:00
License: CC0 · commercial use OK