All TGF-β ligands are expressed in peritoneal fluid from women with and without endometriosis.

Vicky J. Young (627900), Jeremy K. Brown (101879), Philippa T. K. Saunders (34887), W. Colin Duncan (209189), Andrew W. Horne (209218)
2015 · doi:10.1371/journal.pone.0106773.g001 · W6960807982
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TGF-β1 levels were significantly increased in peritoneal fluid from women with endometriosis compared to those without, while TGF-β2 and TGF-β3 levels showed no significant differences between the groups.

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This study analyzed transforming growth factor-beta (TGF-β) ligands in the peritoneal fluid of women with and without endometriosis, alongside human peritoneal mesothelial cells cultured in vitro. The researchers found that while all TGF-β ligands were present in both groups, TGF-β1 levels were significantly elevated in the peritoneal fluid of patients with endometriosis compared to controls. Although TGF-β3 showed a trend toward increase in the disease group, this change did not reach statistical significance, whereas TGF-β2 levels remained unchanged between groups. In vitro experiments confirmed that human peritoneal mesothelial cells are capable of secreting TGF-β1 protein. This paper is centrally about endometriosis — specifically examining the role of TGF-β signaling in the peritoneal environment of affected women.

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Abstract

TGF-β1 was significantly increased in peritoneal fluid from women with endometriosis compared to women without. Levels of TGF-β2 do not change between women with and without endometriosis. TGF-β3 levels appear to increase in women with endometriosis however this is not a significant change. Cultured HPMCs secreted TGF-β1 protein in-vitro. n = 12 peritoneal fluid, n = 3 HMPC (*p<0.05).
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The Peritoneum Is Both a Source and Target of TGF-β in Women with Endometriosis Figure 1 All TGF-β ligands are expressed in peritoneal fluid from women with and without endometriosis. TGF-β1 was significantly increased in peritoneal fluid from women with endometriosis compared to women without. Levels of TGF-β2 do not change between women with and without endometriosis. TGF-β3 levels appear to increase in women with endometriosis however this is not a significant change. Cultured HPMCs secreted TGF-β1 protein in-vitro. n = 12 peritoneal fluid, n = 3 HMPC (*p<0.05).

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endometriosis

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