Xin Li

Background: Epigenetic clock based on DNA methylation can estimate the epigenetic age of tissue and cell that can describe the process of aging. However, the exploration of diseases by the epigenetic clock is still an uncharted territory. …

Objective: Endometriosis is an estrogen-dependent chronic disease. The abnormal proliferation and invasion of ectopic stromal cells (ESCs) are important manifestations of endometriosis, and it is necessary to find safer and more effective t…

OBJECTIVE: Endometrial thickness is a prognostic factor for successful pregnancy. This meta-analysis aimed to examine the role of sildenafil citrate on infertile women with a thin endometrium. METHODS: Two investigators independently search…

Endometriosis is an estrogen-dependent disease, and estrogen receptor 2 (ESR2) plays a critical role in the pathogenesis of ovarian endometriosis by promoting cell invasion. Yes-associated protein 1 (YAP1) plays suppressive roles in several…

Steroidogenic factor-1 (SF-1, encoded by NR5A1) and estrogen receptor beta (ERβ, encoded by ESR2), which are highly expressed in endometriotic stromal cells (ESCs), contribute to the pathogenesis of endometriosis, but the regulation mechani…

BACKGROUND: The endometriosis fertility index (EFI) has a predictive value for pregnancy after surgery. In vitro fertilization and embryo transfer (IVF-ET) is a good treatment to infertility. This study aimed to provide external validation …

CASE REPORT A 58-year-old woman with a history of chronic diarrhea and post-menopausal uterine bleeding underwent a routine colonoscopy for colon cancer screening, which demonstrated a large, nearly obstructing mass extending from the proxi…

UnlabelledEstrogen receptor beta (ERβ, encoded by ESR2 gene) and cytochrome P450 aromatase (encoded by CYP19A1 gene) play critical roles in endometriosis, and the levels of insulin-like growth factor-I (IGF-I) in the peritoneal fluid are si…

BackgroundCytochrome P450 aromatase (encoded by the CYP19A1/aromatase gene) plays a critical physiologic role in endometriosis. Metformin is known to suppress prostaglandin E2 (PGE2)-induced CYP19A1 messenger RNA (mRNA) expression in human …

Endometriosis is a common gynecological disorder affecting mostly women of reproductive age. Its presenting symptoms include dysmenorrhea, chronic pelvic pain and infertility. There is a pressing need to develop more efficacious therapeutic…

Etilogy of endometriosis was complex,but cultivation theory is widely accepted.The pathological changes of endometrial was ectopic endometrial cyslical bleeding and the surrounding tissue fibrosis.The growth,infiltration and hemorrhage of e…

OBJECTIVE: To investigate the expression of integrin beta3 and osteopontin (OPN) in eutopic and ectopic endometrium of adenomyosis. METHODS: From January 2007 to July 2008, the endometrium specimens were collected from 43 patients with aden…

Objective To investigate the expression of progesterone receptor subtypes in adenomyosis tissues and eutopic endometrium.Methods Immunohistochemical streptavidin-biotin peroxidase was applied to compare the expressions of progesterone recep…

Endometriosis is defined as endometriotic tissues growing outside the uterine cavity.Essential for its survival is the generation and maintenance of an extensive blood supply both within and surrounding the ectopic tissue.The pathogenesis a…