Gunu R

No ORCID on file · 4 papers in corpus · active 2015-2020
2020
Improved early detection of ovarian cancer using longitudinal multimarker models.
British journal of cancer ·doi:10.1038/s41416-019-0718-9

BackgroundOvarian cancer has a poor survival rate due to late diagnosis and improved methods are needed for its early detection. Our primary objective was to identify and incorporate additional biomarkers into longitudinal models to improve…

2020
Multi-Marker Longitudinal Algorithms Incorporating HE4 and CA125 in Ovarian Cancer Screening of Postmenopausal Women.
Cancers ·doi:10.3390/cancers12071931

Longitudinal CA125 algorithms are the current basis of ovarian cancer screening. We report on longitudinal algorithms incorporating multiple markers. In the multimodal arm of United Kingdom Collaborative Trial of Ovarian Cancer Screening (U…

2020
Serum HE4 and diagnosis of ovarian cancer in postmenopausal women with adnexal masses.
American journal of obstetrics and gynecology ·doi:10.1016/j.ajog.2019.07.031

BackgroundTransvaginal ultrasound and serum CA125 are routinely used for differential diagnosis of pelvic adnexal mass. Use of human epididymis 4 was approved in the United States in 2011. However, there is scarcity of studies evaluating th…

2015
Risk Algorithm Using Serial Biomarker Measurements Doubles the Number of Screen-Detected Cancers Compared With a Single-Threshold Rule in the United Kingdom Collaborative Trial of Ovarian Cancer Screening.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology ·doi:10.1200/jco.2014.59.4945

PurposeCancer screening strategies have commonly adopted single-biomarker thresholds to identify abnormality. We investigated the impact of serial biomarker change interpreted through a risk algorithm on cancer detection rates.Patients and …