Bruno M Fonseca

No ORCID on file · 6 papers in corpus · active 2020-2025

Study types

  • other 2
  • article 1
  • review 1

Condition tags

  • endometriosis 4
  • infertility 1
other 2025
Effects of cannabidiol, cannabichromene, cannabidivarin, cannabigerol and cannabinol in endometrial cells: Implications for endocrine and senescence modulation
Reproductive toxicology (Elmsford, N.Y.) ·doi:10.1016/j.reprotox.2025.109006

Throughout a woman's menstrual cycle, endometrial stromal cells (ESCs) undergo cyclic morphological and functional alterations, involving proliferation, differentiation and senescence, modulated in part by steroid hormones and the endocanna…

article 2022
Increased expression of NLRP3 inflammasome components in granulosa cells and follicular fluid interleukin(IL)-1beta and IL-18 levels in fresh IVF/ICSI cycles in women with endometriosis
Journal of assisted reproduction and genetics ·doi:10.1007/s10815-022-02662-2

The inflammasomes are a family of recently described multi-protein cytoplasmic sensors that orchestrate the inflammatory response and participate in a variety of inflammatory conditions. We hypothesized that the activation of pyrin domain‑c…

2022
The role of macrophages phenotypes in the activation of resolution pathways within human granulosa cells.
Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-022-00983-6

BackgroundInflammatory state within the ovaries can disrupt normal follicular dynamics, leading to reduced oocyte quality and infertility. How the production of inflammatory mediators generated by macrophages with different gene expression …

other 2021
Concentrations of the endocannabinoid N-arachidonoylethanolamine in the follicular fluid of women with endometriosis: the role of M1 polarised macrophages
Reproduction, fertility, and development ·doi:10.1071/RD20247

Although N-arachidonoylethanolamine (AEA; also known as anandamide) is present in human follicular fluid (FF), its regulation remains unknown. Therefore, the aims of the present study were to: (1) investigate the relationships between FF AE…

2021
Low Doses of Resveratrol Protect Human Granulosa Cells from Induced-Oxidative Stress.
Antioxidants (Basel, Switzerland) ·doi:10.3390/antiox10040561

Resveratrol is a phytoalexin present in plant-derived foods, including grape's skin, cocoa, and peanuts. Evidence suggests that it has beneficial effects on human health because of its antioxidant properties. However, there is limited knowl…

review 2020
The fundamental role of the endocannabinoid system in endometrium and placenta: implications in pathophysiological aspects of uterine and pregnancy disorders
Human reproduction update ·doi:10.1093/humupd/dmaa005

BACKGROUND: The endocannabinoid system (ECS) consists of the cannabinoid receptors CB1 and CB2, the main endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG) and their metabolic enzymes N-acylphosphatidylethanolamine-specific…