Karin Wickström

ObjectivesThe minimal important difference can be helpful in interpreting data from clinical trials. The objective of the study was to calculate the minimal important difference for improvement on the VAS scale for women with endometriosis.…

ObjectiveThe objective was to evaluate the effect of lignocaine on cytokine expression and secretion in vitro in peritoneal fluid macrophages and endometriotic stromal cells.DesignExperimental in vitro study on human cells.Population and sa…

BACKGROUND:Endometriosis is a chronic inflammatory disease of unknown origin that can cause severe dysmenorrhea, chronic pain and impaired quality of life. Lignocaine has anti-inflammatory properties and pertubation with lignocaine could be…

Dysmenorrhea and infertility are the primary symptoms of endometriosis. Lignocaine (lidocaine, xylocaine) is an anesthetic that stabilizes membranes by blocking the action potential. The drug is used topically to induce local and regional a…

OBJECTIVE: Pertubation with lidocaine has been shown to reduce pain (on a VAS-scale) in women with endometriosis. A clinical study was performed to evaluate the effect of lidocaine pertubations on quality of life. DESIGN: Double-blind, rand…

OBJECTIVE: The objective of this study was to report the serum concentration of lignocaine after pertubation in patients with endometriosis. DESIGN: Prospective observational study. SETTING: The study was carried out at a gynaecological out…

BACKGROUND: Endometriosis is a chronic inflammatory disease of unknown aetiology that can cause severe dysmenorrhea. Lignocaine has anti-inflammatory properties and exerts effects on nerve endings and intra-peritoneal macrophages. The objec…