Congjian Xu

Adenomyosis is a common gynecological disease, characterized by the existence of endometrium in the myometrium. The pathogenesis of adenomyosis is not fully understood. P21-activated kinase 1 (PAK1) is an effector of small Rho GTPases inclu…

Adenomyosis is a common gynecological disease, characterized by the existence of endometrium in the myometrium. The pathogenesis of adenomyosis is not fully understood. P21-activated kinase 1 (PAK1) is an effector of small Rho GTPases inclu…

Supplemental Material, Figure_S1 for P21-Activated Kinase 1 Overactivates in Eutopic Endometrium of Adenomyosis by Weiwen Zuo, Xiaoyi Wu, Haiou Liu, and Congjian Xu in Reproductive Sciences

Supplemental Material, Figure_S1 for P21-Activated Kinase 1 Overactivates in Eutopic Endometrium of Adenomyosis by Weiwen Zuo, Xiaoyi Wu, Haiou Liu, and Congjian Xu in Reproductive Sciences

Background: Gut microbiota can interact with the central nervous system through the gut-brain axis, thus affecting the host's chronic stress level, such as anxiety and depression. Current researches show that patients with endometriosis oft…

OBJECTIVE: Abdominal adhesions are primarily severe postoperative complications that can cause gynecological problems such as infertility and chronic pelvic pain. Inflammatory mediators are significantly related to adhesion formation, and h…

Chronic inflammation is a well-known epidemiologic factor of ovarian clear cell carcinomas (OCCC), but has an uncertain role in prognosis. We developed a systemic inflammation score (SIS) based on preoperative serum albumin and neutrophil-t…

BACKGROUND: Despite enormous efforts to dissect the role of endometriosis in ovarian cancer development, the difference in prognosis between ovarian cancer patients with or without endometriosis remains elusive. The purpose of this study is…

AIM: To evaluate the efficacy of combined laparoscopy and hysteroscopy compared with traditional uterine curettage in removing the ectopic conceptus and repairing the tissue defect following uterine artery embolization (UAE) management of c…

Generally, most of ovarian cancer cannot be detected until large scale and remote metastasis occurs, which is the major cause of high mortality in ovarian cancer. Therefore, it is urgent to discover metastasis-related biomarkers for the det…

Endometriosis, diagnosed with ectopically implanted endometrial stromal cells (ESC) and epithelial cells to a location outside the uterine cavity, seriously threaten the quality of life and reproductive ability of women, yet the mechanisms …

OBJECTIVE: Mouse bone marrow mesenchymal stem cells (BMSCs) have been demonstrated to differentiate into female endometrial epithelial cells (EECs) in vivo. Our previous studies demonstrated that BMSCs can differentiate in the direction of …

AIM: To investigate whether intrinsic ureteral endometriosis could be managed by laser endoureterotomy. MATERIAL AND METHODS: We studied retrospectively 6 patients with intrinsic ureteral endometriosis who underwent laser endoureterotomy a…

OBJECTIVE: To introduce a model incorporating expected risks for a vaginal procedure based on objective measurements of a patient's characteristics and propose it as a potential tool to assist in the selection of candidates for vaginal surg…

BACKGROUND: RNA interference technology has shown high therapeutic potential for cancer treatment. However, serum instability, poor tissue permeability and non-specific uptake of short interfering RNA (siRNA) limit its administration in viv…

BACKGROUND: Ovarian cancer is predominant of epithelial cell origin and often present at an advanced stage with poor prognosis. Most animal models of ovarian carcinoma yield thecal/granulose cell tumors, rather than adenocarcinomas. The bes…

OBJECTIVE: To investigate the differentiation conditions of bone marrow mesenchymal stem cells (BMSCs) into endometrial epithelial cells and to confirm the effect of 17β-estradiol in this process. STUDY DESIGN: BMSCs were cultured alone or…

Objective To evaluate the effects of spleen-nourishing and qi-enriching herbs on ectopic endometrium in mice of endometriosis and its adhension.Methods Enhanced green fluorescent protein(EGFP) transgenic and wide-type C57BL/6J mice were use…

OBJECTIVE: To investigate the impact of danazol alginate microspheres used for uterine arterial embolization (UAE) on ovarian function and subsequent pregnancy using rabbit as a model. METHODS: A total of 32 female rabbits were divided int…