D S Charnock-Jones

No ORCID on file · 8 papers in corpus · active 1993-2004

Study types

  • article 6
  • other 2

Condition tags

  • endometriosis 8
  • infertility 1
article 2004
Nimesulide, a COX-2 inhibitor, does not reduce lesion size or number in a nude mouse model of endometriosis
Human Reproduction ·doi:10.1093/humrep/deh611

BACKGROUND: Women with endometriosis have elevated levels of cyclooxygenase-2 (COX-2) in peritoneal macrophages and endometriotic tissue. Inhibition of COX-2 has been shown to reduce inflammation, angiogenesis and cellular proliferation. It…

other 2001
Angiogenic growth factor messenger ribonucleic acids in uterine natural killer cells
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jcem.86.4.7418

Angiogenesis is essential for endometrial growth and repair, and disruption of this process may lead to common disorders of women, including menorrhagia and endometriosis. In pregnancy, failure of the endometrial spiral arterioles to underg…

article 2000
Vascular Endothelial Growth Factor Expression in Human Endometrium Is Regulated by Hypoxia1
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jcem.85.1.6229

Endometrial growth and repair after menstruation are associated with profound angiogenesis. Abnormalities in these processes result in excessive or unpredictable bleeding patterns and are common in many women. It is therefore important to u…

article 1997
Decreased levels of the potent regulator of monocyte/macrophage activation, interleukin-13, in the peritoneal fluid of patients with endometriosis
Human Reproduction ·doi:10.1093/humrep/12.6.1307

Endometriosis is characterized by an increase in the number, activation and secretory activity of peritoneal fluid macrophages. Factors regulating the activation of these cells may be important in the pathophysiology of this disease. In thi…

article 1997
Immunolocalization of the apoptosis regulating proteins Bcl-2 and Bax in human endometrium and isolated peritoneal fluid macrophages in endometriosis
Human Reproduction ·doi:10.1093/humrep/12.1.146

Endometriosis, a debilitating disease associated with infertility, is characterized by the prolonged presence of ectopic endometrial tissue and the involvement of activated peritoneal fluid macrophages. Apoptosis, which occurs in both endom…

article 1996
Vascular endothelial growth factor is produced by peritoneal fluid macrophages in endometriosis and is regulated by ovarian steroids.
The Journal of clinical investigation ·doi:10.1172/jci118815

Angiogenesis is important in the pathophysiology of endometriosis, a condition characterized by implantation of ectopic endometrium in the peritoneal cavity. Vascular endothelial growth factor (VEGF) is a potent angiogenic factor involved i…

other 1996
Vascular endothelial growth factor (VEGF) concentrations are elevated in peritoneal fluid of women with endometriosis
Human Reproduction ·doi:10.1093/oxfordjournals.humrep.a019023

Active endometriosis is characterized by hypervascularization both within and surrounding the implant; therefore the presence of angiogenic factors in the peritoneal environment would be of great importance. Vascular endothelial growth fact…

article 1993
Immunohistochemical localization of acidic and basic fibroblast growth factors in normal human endometrium and endometriosis and the detection of their mRNA by polymerase chain reaction
Human Reproduction ·doi:10.1093/oxfordjournals.humrep.a137856

Growth factors play a role in the cyclical growth and vascularization of normal endometrium. Abnormal endometrial proliferation and neovascularization may result in endometriosis. This study determines the presence and localization of acidi…