K M Zeitoun

No ORCID on file · 7 papers in corpus · active 1997-2014

Study types

  • article 3
  • review 3
  • other 1

Condition tags

  • mesh:D004715 6
  • endometriosis 6
article 2014
REVIEW Estrogen biosynthesis in endometriosis: molecular basis and clinical relevance

Conversion of C19 steroids to estrogens is catalyzed by aromatase in human ovary, placenta and extraglandular tissues such as adipose tissue, skin and the brain. Aromatase activity is not detectable in normal endometrium. In contrast, aroma…

review 2000
Aromatase as a Therapeutic Target in Endometriosis
Trends in endocrinology and metabolism: TEM ·doi:10.1016/s1043-2760(99)00216-7
review 2000
Estrogen biosynthesis in endometriosis: molecular basis and clinical relevance
Journal of molecular endocrinology ·doi:10.1677/jme.0.0250035

Conversion of C(19) steroids to estrogens is catalyzed by aromatase in human ovary, placenta and extraglandular tissues such as adipose tissue, skin and the brain. Aromatase activity is not detectable in normal endometrium. In contrast, aro…

article 2000
Expression of dioxin-related transactivating factors and target genes in human eutopic endometrial and endometriotic tissues
American Journal of Obstetrics and Gynecology ·doi:10.1016/s0002-9378(00)70325-5
other 2000
Molecular basis for treating endometriosis with aromatase inhibitors
Human reproduction update ·doi:10.1093/humupd/6.5.413

Although treatment of one unusually aggressive case of postmenopausal endometriosis with an aromatase inhibitor has been strikingly successful, large clinical trials are required to establish whether aromatase inhibitors will have a signifi…

review 1999
Aromatase: a key molecule in the pathophysiology of endometriosis and a therapeutic target
Fertility and Sterility ·doi:10.1016/s0015-0282(99)00393-3
article 1997
Prostaglandin E2Stimulates Aromatase Expression in Endometriosis-Derived Stromal Cells1
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jcem.82.2.3783

C19 steroids are converted to estrogens by aromatase P450 (P450arom). Aromatase expression in humans is regulated by use of tissue-specific promoters in the placenta (promoter I.1), adipose tissue (promoters I.4, I.3, and II), and gonads (p…