Yang M

PURPOSE: Adenomatoid tumor (AT) of the uterus is a rare benign neoplasm of mesothelial origin. To date, few studies have reported the magnetic resonance imaging (MRI) findings and clinicopathologic features of uterine ATs. This study aimed …

OBJECTIVE: In recent years, advancements in metabolomics have highlighted that changes in metabolic states within the body might also be closely related to missed abortion. However, the specific impacts of metabolic abnormalities on missed …

BACKGROUND: Aspartame, a widely used artificial sweetener, has been implicated in multiple toxicities. However, its potential reproductive toxicity mechanisms remain unclear. This study aimed to investigate the underlying relationship betwe…

Research on the association between urinary heavy metals, phthalates, phytoestrogens (PEs), polycyclic aromatic hydrocarbons (PAHs), and endometriosis (EM) is limited. Data were from the National Health and Nutrition Examination Survey 1999…

OBJECTIVE: This retrospective cohort study investigated the association between estradiol (E2), progesterone (P) levels on human chorionic gonadotropin (HCG) day and the pregnancy outcomes of fresh embryo transfer cycles in In Vitro Fertili…

BACKGROUND: This study evaluated the effects of different ovulation trigger strategies on pregnancy outcomes in letrozole-stimulated and modified natural frozen–thawed embryo transfer (L-FET and mNC-FET) cycles. METHODS: A total of 2053 eli…

PURPOSE: To systematically evaluate and compare the quality, readability, and query-model consistency of adenomyosis-related content generated by two large language models, ChatGPT (GPT-5) and DeepSeek (R1). MATERIALS AND METHODS: In total…

Leuprolide and Goserelin, both gonadotropin-releasing hormone (GnRH) agonists, are commonly used for ovarian function suppression and the management of hormone-dependent cancers. However, systematic comparisons of their adverse event (AE) p…

ObjectivesThis study aimed to report a concept analysis of fertility protection and elucidate a current definition.MethodsThis study adopted Rodgers's evolutionary and inductive method of concept analysis. Literature from January 1990 to Ma…

OBJECTIVE: To estimate the risk of cesarean scar diverticulum associated with the timing of cesarean section. PATIENTS AND METHODS: This was a retrospective cohort study involving three Chinese hospitals. A total of 11,132 women were inclu…

This study explored the genetic evidence linking triglyceride-related pathways and lipid-lowering drug targets with endometriosis risk and investigated the genetic association between TG levels and EM. Using genome-wide association study (G…

Endometriosis is a common gynecological disorder that requires accurate detection of ectopic lesions in laparoscopic images for effective diagnosis and treatment. However, existing deep learning-based detection methods face significant chal…

BACKGROUND: The clinical management of adenomyosis remains challenging. Pharmacological therapies and surgical approaches for adenomyosis have shown benefits but present important limitations, such as side effects, recurrence, and loss of f…

BACKGROUND: Endometriosis (EMS) is an estrogen-dependent chronic inflammatory disorder for which metabolic reprogramming has emerged as a central pathological feature. Driven by genetic, epigenetic, and microenvironmental stressors, ectopic…

BACKGROUND: Optimal endometrial thickness and receptivity, precisely regulated by steroid hormones, are critical determinants for successful embryo implantation. Thin endometrium is a major cause of female infertility, yet its pathogenesis …

Endometriosis (EMs) is an estrogen-dependent, chronic inflammatory disorder characterized by immune microenvironment dysregulation, a critical factor in its pathogenesis. Despite existing therapies, limitations persist, highlighting the urg…

BACKGROUND: Ovarian endometriosis (OEMs) is a primary cause of female infertility and is driven primarily by fibrosis, which disrupts the ovarian follicular microenvironment. Pirfenidone (PFD), an FDA-approved antifibrotic drug, holds promi…

OBJECTIVE: To study the MRI characteristics of adenomyosis in secondary infertility patients, and to analyze the factors affecting pregnancy after High-intensity focused ultrasound (HIFU). METHODS: Clinical data of 388 patients with adenom…

BACKGROUND: This phase 2 trial comprised dose exploration (stage 1) and dose confirmation stages (stage 2) to determine the safety and efficacy of HSK21542 in patients undergoing laparoscopic abdominal surgery. METHODS: In stage 1, patient…

Pancreatitis, an inflammatory disorder of the pancreas, remains a significant clinical challenge owing to its complex pathogenesis and the lack of reliable biomarkers for early diagnosis and effective treatment. Exosomes, small extracellula…

Diminished ovarian reserve (DOR) poses significant challenges in reproductive health, with emerging evidence implicating DNA damage repair pathways. While GADD45A is a critical regulator of DNA repair, cell cycle and apoptosis, its role in …

OBJECTIVE: To evaluate whether the timing of adenomyomectomy within the menstrual cycle influences outcomes in patients with adenomyosis, and to assess whether surgery performed during the secretory phase offers clinical advantages over the…

Endometriosis (EM) is a chronic, estrogen-dependent disease characterized by the ectopic presence of endometrial-like tissue. Despite extensive research, its molecular pathogenesis remains unclear. In this study, we conducted an integrated …

PURPOSE: Endometriosis is characterized by the ectopic growth of endometrial-like tissue outside the uterus and altered energy metabolism, but the specific mechanisms involved remain unclear. This study aimed to investigate the impact of Si…