Joe A. Arosh — Endo Lab

lab-animal 2012

Selective Inhibition of Prostaglandin E2 Receptors EP2 and EP4 Inhibits Growth of Experimental Endometriosis in Nude Mice Evaluated by Real-time Noninvasive Imaging and Fluorescence Microscopy.

·doi:10.1093/biolreprod/87.s1.550

Endometriosis is a highly prevalent estrogen-dependent gynecological inflammatory disease of reproductive-age women characterized by the presence of functional endometrial cells outside the uterus commonly leading to inflammation, pain and …

2011

Faculty Opinions recommendation of Experimental endometriosis in immunocompromised mice after adoptive transfer of human leukocytes.

·doi:10.3410/f.1162825.11112056

2011

Faculty Opinions recommendation of Prostaglandin E2: the master of endometriosis?

·doi:10.3410/f.13109957.14433055

lab-animal 2011

Preconception omega-3 fatty acid supplementation of adult male mice with a history of developmental 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure prevents preterm birth in unexposed female partners

Reproduction (Cambridge, England) ·doi:10.1530/rep-11-0070

We have recently reported that adult male C57BL/6 mice exposed in utero to the environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) confer an increased risk of preterm birth (PTB) to unexposed females. Risk of PTB was coinciden…

lab-animal 2010

Expression and Regulation of Prostaglandin Biosynthetic Enzymes Cox-2 and Pges-1 and Receptors EP1, EP2, EP3, and EP4 in Endometriosis in the Nonhuman Primate.

·doi:10.1093/biolreprod/83.s1.168

Endometriosis is a debilitating disease where endometrium-like tissue forms lesions outside the uterus that result in chronic pelvic pain and infertility in 10-20% of women of reproductive age. Endometriosis is an estrogen-dependent disease…

2010

Faculty Opinions recommendation of A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis with an antiangiogenic effect in a rat model.

·doi:10.3410/f.7014956.7223054

2010

Faculty Opinions recommendation of Inhibition of CD36-dependent phagocytosis by prostaglandin E2 contributes to the development of endometriosis.

·doi:10.3410/f.1582957.2501057

2010

Faculty Opinions recommendation of Prostaglandin E2 via steroidogenic factor-1 coordinately regulates transcription of steroidogenic genes necessary for estrogen synthesis in endometriosis.

·doi:10.3410/f.5294956.5238054

2010

Faculty Opinions recommendation of The treatment with a COX-2 specific inhibitor is effective in the management of pain related to endometriosis.

·doi:10.3410/f.3541956.3241054

lab-animal 2010

Selective blockade of prostaglandin E2 receptors EP2 and EP4 signaling inhibits proliferation of human endometriotic epithelial cells and stromal cells through distinct cell cycle arrest

Fertility and sterility ·doi:10.1016/j.fertnstert.2010.01.038

OBJECTIVE: To determine interactions between prostaglandin (PG) E(2) signaling and proliferation of endometriotic cells to increase our knowledge about PGE(2) signaling in the pathogenesis of endometriosis in humans. DESIGN: Immortalized h…

2010

Selective inhibition of prostaglandin E2 receptors EP2 and EP4 inhibits adhesion, migration, and invasion of human endometriotic cells

·doi:10.1016/j.fertnstert.2010.07.783

lab-animal 2010

Selective inhibition of prostaglandin E2 receptors EP2 and EP4 inhibits invasion of human immortalized endometriotic epithelial and stromal cells through suppression of metalloproteinases

Molecular and cellular endocrinology ·doi:10.1016/j.mce.2010.11.022

Prostaglandin E2 (PGE2) plays an important role in the pathogenesis of endometriosis. We recently reported that inhibition of COX-2 decreased migration as well as invasion of human endometriotic epithelial and stromal cells. Results of the …

2009

PPAR-gamma ligand activation decreases p450 aromatase gene expression in human endometriotic epithelial and stromal cells in vitro

·doi:10.1016/j.fertnstert.2009.07.046

lab-animal 2009

Prostaglandin E2 Regulates Survival of Human Endometriotic Epithelial and Stromal Cells by Integrating EGFR, NFkB, and Wnt Signaling Pathways Through EP2 and EP4 Receptors.

·doi:10.1093/biolreprod/81.s1.150

Endometriosis is a debilitating disease affects up to 20% of reproductive age women characterized by the presence of functional endometrial glandular epithelium and stroma outside the uterine cavity that results in chronic pelvic pain and i…

lab-animal 2009

Selective inhibition of prostaglandin E2 receptors EP2 and EP4 induces apoptosis of human endometriotic cells through suppression of ERK1/2, AKT, NFkappaB, and beta-catenin pathways and activation of intrinsic apoptotic mechanisms

Molecular Endocrinology ·doi:10.1210/me.2009-0017

Endometriosis is a benign chronic gynecological disease of reproductive-age women characterized by the presence of functional endometrial tissues outside the uterine cavity. It is an estrogen-dependent disease. Current treatment modalities …

lab-animal 2009

Selective Inhibition of Prostaglandin E2 Receptors EP2 and EP4 Induces Apoptosis of Human Endometriotic Cells through Suppression of ERK1/2, AKT, NFκB and β-CATENIN Pathways and Activation of Intrinsic Apoptotic Mechanisms

·doi:10.1210/jcem.94.7.9993

Endometriosis is a benign chronic gynecological disease of reproductive age women characterized by the presence of functional endometrial tissues outside the uterine cavity. It is an estrogen-dependent disease. Current treatment modalities …

2009

Selective inhibition of prostaglandin E2 signaling inhibits migration and invasion of human endometriotic epithelial and stromal cells through multiple mechanisms

·doi:10.1016/j.fertnstert.2009.07.043

lab-animal 2008

Induction of peritoneal endometriosis in nude mice with use of human immortalized endometriosis epithelial and stromal cells: a potential experimental tool to study molecular pathogenesis of endometriosis in humans

Fertility and sterility ·doi:10.1016/j.fertnstert.2008.06.050

OBJECTIVE: To determine whether a mixed population of immortalized human endometriosis epithelial and stromal cells is able to induce peritoneal endometriosis in nude mice. DESIGN: Prospective experimental study. Human immortalized endomet…

other 2007

Cyclooxygenase-2 regulates survival, migration, and invasion of human endometriotic cells through multiple mechanisms

Endocrinology ·doi:10.1210/en.2007-1168

Endometriosis is a debilitating disease characterized by the presence of functional endometrial glandular epithelium and stroma outside the uterine cavity that affects up to 20% of women of child-bearing age. Cyclooxygenase-2 (COX-2), a rat…

lab-animal 2007

Gene expression profiles and functional characterization of human immortalized endometriotic epithelial and stromal cells

Fertility and sterility ·doi:10.1016/j.fertnstert.2007.07.1358

OBJECTIVE: To determine whether immortalized endometriotic cells can be used as potential models to unravel pathophysiology/pathogenesis of endometriosis in humans. DESIGN: In vitro study. Human immortalized endometriotic epithelial and st…

lab-animal 2007

GENE EXPRESSION PROFILES IN HUMAN IMMORTALIZED ENDOMETRIOTIC EPITHELIAL AND STROMAL CELLS: CYCLOOXYGENASE-2 REGULATES CELL PROLIFERATION, MIGRATION AND INVASION

·doi:10.1093/biolreprod/77.s1.158

Endometriosis is a debilitating disease affects up to 20% of reproductive age women characterized by the presence of functional endometrial glandular epithelium and stroma out side the uterine cavity. The pathophysiology of endometriosis re…

lab-animal 2007

PROSTAGLANDIN E2 SIGNALING IN PATHOPHYSIOLOGY OF ENDOMETRIOSIS IN HUMAN

·doi:10.1093/biolreprod/77.s1.157b

Endometriosis is a debilitating disease affects up to 20% of reproductive age women characterized by the presence of functional endometrial glandular epithelium and stroma out side the uterine cavity. The pathophysiology of endometriosis re…