Racowsky C

PurposeTo determine correlations between chemicals in follicular fluid (FF) and follicular reproductive hormone levels.MethodsThe analysis was part of a larger cohort study to determine associations between exposure to EDCs and in vitro fer…

ObjectiveTo identify independent risk factors for placenta accreta spectrum among pregnancies conceived with assisted reproductive technology.DesignRetrospective cohort study.SettingTertiary hospital.PatientsIndividuals who conceived with a…

ObjectiveTo describe the initiation, integration, and costs of reduced-cost infertility services within the maternal health department of a public hospital in a low-income country.DesignRetrospective review of the clinical and laboratory co…

PurposeTo compare the expression profile of extracellular vesicle microRNAs (EV-miRNAs) derived from follicular fluid after a trigger with recombinant human chorionic gonadotropin (r-hCG) or with a gonadotropin-releasing hormone GnRH agonis…

PurposeSupraphysiologic serum estradiol levels may negatively impact the likelihood of conception and live birth following IVF. The purpose of this study is to determine if there is an association between serum estradiol level on the day of…

OBJECTIVE: To define specific risk factors for placenta previa in pregnancies conceived with assisted reproductive technology (ART). DESIGN: Retrospective cohort. SETTING: Fertility centers and inpatient obstetric units in Massachusetts. …

PurposeDuring a typical IVF cycle, there is unavoidable attrition from oocytes retrieved to blastocysts formed. Some patients will not have blastocysts available to biopsy or embryos for transfer. The purpose of this study was to predict th…

ObjectiveTo compare the obstetric and perinatal outcomes of deliveries conceived with embryos from single-step vs. sequential culture media systems.DesignHistorical cohort of Massachusetts vital records linked to assisted reproductive techn…

ObjectiveThe primary objective of this study was to test the hypotheses that compared to IVF cycles undergoing preimplantation genetic testing for aneuploidy (PGT-A) with or without testing for monogenic disorders (PGT-M), IVF cycles underg…

PurposeTo test whether an electronic whiteboard in the IVF laboratory increases the likelihood that critical evaluation procedures are performed within optimum pre-set time ranges.MethodsA retrospective cohort study of oocyte retrievals in …

Macroscopic, phenomenological models are useful as concise framings of our understandings in fields from statistical physics to finance to biology. Constructing a phenomenological model for development would provide a framework for understa…

BackgroundMore than 67% of all embryos transferred in the United States involve frozen-thawed embryos. Progesterone supplementation is necessary in medicated cycles to luteinize the endometrium and prepare it for implantation, but little da…

BackgroundThe optimal route of progesterone administration for luteal support in cryopreserved embryo transfer (CET) has been the subject of much debate. While most published research has pertained to day 3 transfers, recent data on blastoc…

PurposeTo assess whether machine learning methods provide advantage over classic statistical modeling for the prediction of IVF outcomes.MethodsThe study population consisted of 136 women undergoing a fresh IVF cycle from January 2014 to Au…

ObjectiveTo study whether increased body mass index is associated with altered expression of extracellular vesicle microRNAs (EV-linked miRNAs) in human follicular fluid.DesignCross-sectional study.SettingTertiary-care university-affiliated…

Research questionWhat is the association between endometrioma-affected ovaries, their follicular fluid inflammatory microenvironment, and ovary-specific oocyte and embryo yield and quality?DesignExposure-matched prospective cohort study con…

Bisphenol A (BPA) is a widely used chemical that has been detected in follicular fluid and associated with adverse reproductive effects. Granulosa cells have an important role in follicular growth and oocyte maturation, however, little is k…

BackgroundPhenols and phthalates are potential endocrine disrupting chemicals (EDCs) that are associated with adverse health outcomes. These EDCs dysregulate a number of biomolecules and pathways, including microRNAs. MicroRNAs can be carri…

PurposeThe purpose of this study is to investigate whether abnormal hCG trends occur at a higher incidence among women conceiving singleton pregnancies following transfer of multiple (two or more) embryos (MET), as compared to those having …

Encapsulated microRNAs (i.e., miRNAs within the extracellular vesicles, i.e., EV-miRNAs) have been detected in follicular fluid in both animal and human studies and different profiles have been associated with IVF cycle characteristics. How…

PurposeDespite studies focused on the association between embryo morphology and implantation potential, it is unknown how the collective quality of the supernumerary embryos in a cohort is associated with the implantation rate (IR) of the t…

PurposeTo determine the expected out-of-pocket costs of IVF with preimplantation genetic testing for aneuploidy (PGT-A) to attain a 50%, 75%, or 90% likelihood of a euploid blastocyst based on individual age and AMH, and develop a personali…

PurposeWe examined whether short-term exposure to in vitro maturation (IVM) medium of cumulus-oocyte complexes (COCs) from a stimulated cycle increases the yield of metaphase II (MII) oocytes and usable embryos.MethodsRetrospective review o…

Phthalates are a class of chemicals found in a large variety of consumer products. Available experimental and limited human data show adverse effects of some phthalates on ovarian function, which has raised concerns regarding potential effe…

ObjectiveTo study whether maternal intake of beverage type affects IVF outcomes.DesignA prospective study.SettingTertiary, university-affiliated center.Patient(s)Three hundred forty women undergoing IVF from 2014 through 2016 for infertilit…