Hauser R

Study questionWhat is the association of female and male partner marijuana smoking with infertility treatment outcomes with ART?Summary answerWomen who were marijuana smokers at enrollment had a significantly higher adjusted probability of …

Research questionStudies in rodents have shown that paternal folate intake prior to conception is associated with pregnancy and offspring outcomes. The aim of this study was to assess whether those associations might apply to humans as well…

BackgroundIdentification of female reproductive toxicants is currently based largely on integrated epidemiological and in vivo toxicology data and, to a lesser degree, on mechanistic data. A uniform approach to systematically search, organi…

Traffic-related air pollution has been linked to higher risks of infertility and miscarriage. We evaluated whether folate intake modified the relationship between air pollution and livebirth among women using assisted reproductive technolog…

Bisphenol A (BPA) is a widely used chemical that has been detected in follicular fluid and associated with adverse reproductive effects. Granulosa cells have an important role in follicular growth and oocyte maturation, however, little is k…

BackgroundWe have previously investigated whether urinary concentrations of bisphenol A (BPA), parabens, and phthalate metabolites were individually associated with reproductive outcomes among women undergoing in vitro fertilization (IVF) t…

BackgroundPhenols and phthalates are potential endocrine disrupting chemicals (EDCs) that are associated with adverse health outcomes. These EDCs dysregulate a number of biomolecules and pathways, including microRNAs. MicroRNAs can be carri…

Study questionAre urinary levels of oxidative stress biomarkers associated with reproductive outcome success following fertility treatments?Summary answerLevels of oxidative stress in the middle tertile for women are associated with the hig…

ImportanceAnimal experiments suggest that ingestion of pesticide mixtures at environmentally relevant concentrations decreases the number of live-born offspring. Whether the same is true in humans is unknown.ObjectiveTo examine the associat…

BackgroundWhile overt thyroid disease is a well known risk factor for infertility, the potential consequences of mild thyroid dysfunction or thyroid autoimmunity remain unknown. Experimental studies suggest a considerable role for thyroid h…

Encapsulated microRNAs (i.e., miRNAs within the extracellular vesicles, i.e., EV-miRNAs) have been detected in follicular fluid in both animal and human studies and different profiles have been associated with IVF cycle characteristics. How…

BackgroundSome dietary factors have been linked to outcomes of infertility treatment with assisted reproductive technology (ART), but the role of intake of meats and other protein-rich foods remains unclear.ObjectiveThe aim of this manuscri…

ObjectiveTo evaluate whether urinary concentrations of organophosphate flame retardant (PFR) metabolites are associated with pregnancy loss among women conceiving with assisted reproductive technology (ART).DesignProspective preconception c…

Study questionAre serum polyunsaturated fatty acids (PUFA) concentrations, including omega-3 (ω3-PUFA) and omega-6 (ω6-PUFA), related to ART outcomes?Summary answerSerum levels of long-chain ω3-PUFA were positively associated with probabili…

BackgroundThe Environment and Reproductive Health (EARTH) Study is an ongoing prospective preconception cohort designed to investigate the impact of environmental, nutritional, and lifestyle factors among both women and men on fertility and…

BackgroundSubfertile women are at increased risk of glucose intolerance in pregnancy. Based on epidemiologic studies, exposure to certain phthalates is associated with diabetes, elevated glucose, and increased insulin resistance.ObjectivesT…

Phthalates are a class of chemicals found in a large variety of consumer products. Available experimental and limited human data show adverse effects of some phthalates on ovarian function, which has raised concerns regarding potential effe…

ObjectiveTo study whether maternal intake of beverage type affects IVF outcomes.DesignA prospective study.SettingTertiary, university-affiliated center.Patient(s)Three hundred forty women undergoing IVF from 2014 through 2016 for infertilit…

Study questionDoes bisphenol-A (BPA) affect gene expression in human membrana granulosa cells (MGC)?Summary answerIn vitro, short exposure to supra-physiological concentrations of BPA alters human MGC gene expression.What is known alreadyEx…

BackgroundCigarette smoking has been associated with worse infertility treatment outcomes, yet some studies have found null or inconsistent results.MethodsWe followed 225 couples who underwent 354 fresh non-donor assisted reproductive techn…

PurposeThe purpose of this study is to determine the profile of extracellular microRNAs (exmiRNAs) in follicular fluid (FF) and explore their association with fertilization potential and embryo quality.MethodsWe collected FF from single fol…

Much of the literature on the impact of male caffeine and alcohol intake on reproductive outcomes has utilized semen quality as a proxy for male fertility, although semen parameters have a limited predictive value for spontaneous pregnancy.…

ObjectivesTo explore whether work schedules and physically demanding work were associated with markers of ovarian reserve and response.MethodsThis analysis included women (n=473 and n=313 for ovarian reserve and ovarian response analysis, r…

Higher concentrations of certain phthalate metabolites are associated with adverse reproductive and pregnancy outcomes, as well as poor infant/child health outcomes. In non-pregnant populations, phthalate metabolite concentrations vary by r…

Study questionIs pre-treatment alcohol and caffeine intake associated with infertility treatment outcomes among women undergoing ART?Summary answerLow to moderate alcohol and caffeine intakes in the year prior to infertility treatment were …