Ov D. Slayden

Endometriosis is an estrogen-dependent disorder defined by endometrium-like tissue outside the uterine cavity that results in pelvic inflammation. Pro-inflammatory cytokines can increase 11 β -hydroxysteroid dehydrogenase type 1 (11β-HSD1),…

Background: Endometriosis is a painful disorder in women where endometrium-like tissue exists outside of the uterine cavity. Progress on new therapies for the disorder is dependent on physiologically relevant models. Menstruation and develo…

STUDY QUESTION: Does chronic hyperandrogenemia beginning at menarche, in the absence and presence of a western-style diet (WSD), alter ovarian and uterine structure-function in young adult rhesus monkeys? SUMMARY ANSWER: Phenotypic alterat…

BACKGROUND: We evaluated whether menstrual cycle phase influences the assessment of tubal patency by hysterosalpingography (HSG) in baboons. METHODS: Retrospective analysis of baseline tubal patency studies and serum estradiol (E2 ) and pr…

Human uterine fibroids, benign tumors derived from the smooth muscle layers of the uterus, impose a major health burden to up to 50 % of premenopausal women in their daily life. To improve our understanding of this disease, we developed and…

Macaques and baboons display physiological responses to steroid hormones that are similar to those of women. Herein, we describe various uses of nonhuman primates for preclinical studies on menstruation, endometriosis, and as a model system…

OBJECTIVE: To demonstrate the feasibility of polidocanol foam (PF) as a nonsurgical method of female permanent contraception using a nonhuman primate model. STUDY DESIGN: Four groups of adult female rhesus macaques underwent either transce…

In this month's issue of Biology of Reproduction, Afshar et al. report on the effects of endometriosis on gene expression in the baboon endometrium.

The hormonally driven expression and cell-specific localization patterns of the progesterone receptor membrane components (PGRMC1 and PGRMC2) in the macaque endometrium during the menstrual cycle are unknown. Additionally, the expression an…

Many women suffer from unwanted heavy menstrual bleeding. Macaques are menstruating nonhuman primates that provide the most physiologically relevant model for preclinical studies of heavy menstrual bleeding. Angiogenic factors including vas…

Alterations in progesterone receptor membrane component 2 (PGRMC2) in the endometrium of macaques afflicted with advanced endometriosis

Much of our understanding of the molecular control of menstruation arises from laboratory models that experimentally recapitulate some, but not all, aspects of uterine bleeding observed in women. These models include: in vitro culture of en…

Endometriosis is a painful disorder for millions of women worldwide. It is identified by endometrium-like tissue outside the uterine cavity, and results in chronic pelvic pain and subfertility. Spontaneous endometriosis only occurs in women…

Objective: Endometriosis is a disorder where endometrium-like tissues form lesions at ectopic sites outside of the uterus. Spontaneous endometriosis occurs only in women and menstruating nonhuman primates (NHPs). Progress on new therapies f…

Endometriosis is a debilitating disease where endometrium-like tissue forms lesions outside the uterus that result in chronic pelvic pain and infertility in 10-20% of women of reproductive age. Endometriosis is an estrogen-dependent disease…

BACKGROUND: Ulipristal (UPA; CDB-2914) is a progesterone receptor modulator with contraceptive potential. To test its effects when delivered by an intrauterine system (IUS), we prepared control and UPA-filled IUS and evaluated their effects…

For the report, Dr Slayden, Dr Wilk and Ms Carroll did not have the opportunity to examine and contribute to this manuscript. Dr Slayden and Ms Carroll were responsible for providing progesterone implants for treatment of the animals. Dr Wi…

We have continued to explore the 3,3-dialkyl-5-aryloxindole series of progesterone receptor (PR) modulators looking for new agents to be used in female healthcare: contraception, fibroids, endometriosis, and certain breast cancers. Previous…