Ov D. Slayden — Endo Lab

2007

Effects of a novel selective estrogen receptor modulator (SERM) on cell proliferation and growth in a macaque autograft model for endometriosis

·doi:10.1016/j.fertnstert.2007.07.207

review 2006

Role of nonhuman primate models in the discovery and clinical development of selective progesterone receptor modulators (SPRMs)

Reproductive biology and endocrinology : RB&E ·doi:10.1186/1477-7827-4-s1-s8

Selective progesterone receptor modulators (SPRMs) represent a new class of progesterone receptor ligands that exert clinically relevant tissue-selective progesterone agonist, antagonist, partial, or mixed agonist/antagonist effects on vari…

review 2004

Hormonal regulation and localization of estrogen, progestin and androgen receptors in the endometrium of nonhuman primates: effects of progesterone receptor antagonists

Archives of histology and cytology ·doi:10.1679/aohc.67.393

This article reviews the effects of estradiol (E(2)), progesterone (P) and P receptor antagonists (PA) on the rhesus macaque endometrium. Ovariectomized macaques can be treated with implants of estradiol (E(2)) and P to induce precisely con…

lab-animal 2004

Human endometriotic xenografts in immunodeficient RAG-2/gamma(c)KO mice

American journal of obstetrics and gynecology ·doi:10.1016/j.ajog.2004.02.047

OBJECTIVE: The purpose of this study was to create a novel animal model for studies of endometriosis. STUDY DESIGN: To facilitate the study of the transplantation of endometriosis into immunodeficient RAG-2/gamma(c)KO mice, endometriosis b…

other 2002

Premenstrual and menstrual changes in the macaque and human endometrium: relevance to endometriosis

Annals of the New York Academy of Sciences ·doi:10.1111/j.1749-6632.2002.tb02766.x

According to current theory, endometriosis is initiated during retrograde menstruation when menstrual fragments flow out of the fimbriated end of the fallopian tubes and become established on the ovarian surface or other sites in the perito…

nonrandomized-trial 2000

Progesterone withdrawal up-regulates vascular endothelial growth factor receptor type 2 in the superficial zone stroma of the human and macaque endometrium: potential relevance to menstruation

The Journal of clinical endocrinology and metabolism ·doi:10.1210/jcem.85.9.6769

Several reports indicate that vascular endothelial growth factor (VEGF) expression is increased in endometrial glands and stroma during the menstrual phase in the human endometrium. Here we report that VEGF receptor type 2 (KDR), normally e…