Rivier J

No ORCID on file · 7 papers in corpus · active 1982-2013

Study types

  • article 3
  • other 1

Condition tags

  • endometriosis 4
2013
Key role of CRF in the skin stress response system.
Endocrine reviews ·doi:10.1210/er.2012-1092

The discovery of corticotropin-releasing factor (CRF) or CRH defining the upper regulatory arm of the hypothalamic-pituitary-adrenal (HPA) axis, along with the identification of the corresponding receptors (CRFRs 1 and 2), represents a mile…

2006
Novel analogues of degarelix incorporating hydroxy-, methoxy-, and pegylated-urea moieties at positions 3, 5, 6 and the N-terminus. Part III.
Journal of medicinal chemistry ·doi:10.1021/jm060240a

Novel degarelix (Fe200486) analogues were screened for antagonism of GnRH-induced response (IC(50)) in a reporter gene assay. Inhibition of luteinizing hormone release over time was measured in the castrated male rat. N(omega)-Hydroxy- and …

2005
Iterative approach to the discovery of novel degarelix analogues: substitutions at positions 3, 7, and 8. Part II.
Journal of medicinal chemistry ·doi:10.1021/jm050134t

Degarelix (FE200486, Ac-d-2Nal(1)-d-4Cpa(2)-d-3Pal(3)-Ser(4)-4Aph(l-Hor)(5)-d-4Aph(Cbm)(6)-Leu(7)-ILys(8)-Pro(9)-d-Ala(10)-NH(2)) is a potent and very long acting antagonist of gonadotropin-releasing hormone (GnRH) after subcutaneous admini…

other 1984
Stimulation of LH fragments with reduced bioactivity following GnRH agonist administration in women
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jcem-58-4-755

In eumenorrheic women with endometriosis and in oligo-amenorrheic women with polycystic ovarian disease (PCO), chronic administration of a long-acting GnRH agonist (GnRH-a) reduced the circulating concentrations of estrogens and androgens t…

article 1983
Hormonal effects of danazol and medical oophorectomy in endometriosis.
Obstetrics and gynecology

The hormonal effects of danazol and of a long-acting gonadotropin-releasing hormone analogue (GnRH-a) were studied in women with endometriosis and those with oophorectomy. During danazol treatment, total serum concentrations of estrone and …

article 1983
Induction of Hot Flashes in Premenopausal Women Treated with a Long-Acting GnRH Agonist*
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jcem-56-3-445

To examine the relationship between the occurrence of menopausal hot flashes and the pulsatile release of LH, we have investigated the serum hormone levels and the occurrence of hot flashes by objective recordings in five women with endomet…

article 1982
“MEDICAL OOPHORECTOMY” USING A LONG-ACTING GNRH AGONIST-A POSSIBLE NEW APPROACH TO THE TREATMENT OF ENDOMETRIOSIS.
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jcem-54-5-1081

Five women with endometriosis were given a daily dose of a potent long-acting GnRH agonist, D-Trp6-Pro9-Net-LHRH (GnRH-A) for 28 days in an attempt to suppress ovarian estrogen secretion. The mean level of estradiol (E2) during sampling ove…