Huang C

IntroductionPCOS is the most common disorder encompassing reproductive, metabolic, and endocrine abnormalities, and has an increased risk of adverse pregnancy and neonatal complications, such as miscarriage, gestational diabetes mellitus, a…

OBJECTIVE: To compare the efficacy of different COH protocols on pregnancy outcomes in adenomyosis patients. STUDY DESIGN: A real-world retrospective cohort study analyzed 1486 IVF-ET cycles in adenomyosis patients who received COH regimen…

BACKGROUND: Laparoscopic ovarian cystectomy for endometriosis carries a substantial risk of diminished ovarian reserve. Optimal intraoperative hemostasis remains uncertain, and predictive tools for postoperative ovarian function are limited…

Cervical cancer has become a glaring concern for women's health globally. The use of single-cell RNA sequencing (scRNA-seq) contributes to a comprehensive understanding of cellular heterogeneity and the immune cell landscape in the TME of c…

To evaluate the effectiveness of subendometrial autologous platelet-rich plasma (PRP) injections in improving endometrial thickness (EMT) and pregnancy outcomes in women with refractory thin endometrium. This prospective, single-arm, self-c…

BackgroundThin endometrium continues to pose a significant challenge in assisted reproductive technology (ART) cycles, necessitating further exploration of therapeutic approaches. Tamoxifen (TMXF) has been primarily used in ovarian stimulat…

BackgroundTo assess sequential embryo transfer's impact on clinical outcomes in frozen embryo transfer (FET) cycles for patients with multiple transfer failures.MethodsThis retrospective cohort study encompasses 4,499 FET cycles involving d…

PurposeAcute pancreatitis (AP) is an inflammatory disorder with rising global incidence. Substantial progress in elucidating AP pathophysiology has been achieved over the past two decades. This study aims to assess the evolution of AP patho…

ObjectiveTo identify the key factors associated with biochemical pregnancy loss (BPL) following single blastocyst transfer in frozen embryo transfer (FET) cycles utilizing hormone replacement therapy (HRT).MethodsThis retrospective cohort s…

Objective: Endometriosis affects 1 in 10 women of reproductive age worldwide, yet there is no accurate non-invasive diagnostic test that would help triage patients into the best practice treatment pathway. We aimed to identify a diagnostic …

PURPOSE: To determine whether presence of endometriomas on routine pelvic ultrasound (US) can predict presence of deep infiltrating endometriosis (DE) on magnetic resonance imaging (MRI) and correlate endometrioma size with the presence of …

Biofilms increase bacterial resistance to antibiotics, as conventional antibiotic doses are often ineffective at penetrating the biofilm matrix to eliminate bacteria. Recent research has shown that the Gram-negative predator bacterium Bdell…

Protein O-GlcNAcylation is a post-translational modification coupled to cellular metabolic plasticity. Aberrant O-GlcNAcylation has been observed in many cancers including endometrial cancer (EC), a common malignancy in women. However, clin…

ObjectiveTo develop a predictive tool in the form of a Nomogram based on the Cox regression model, which incorporates the impact of the length of treatment cycles on the outcome of live birth, to evaluate the probability of infertile couple…

BackgroundThe achievement of a healthy live birth from a singleton pregnancy has become the primary objective of modern Assisted Reproductive Technology (ART). Consequently, the effective utilization of a single blastocyst is of paramount i…

OBJECTIVE: Endometriosis increases ovarian cancer (OC) risk through genetic mutations, chronic inflammation, and hormonal dysregulation, yet the underlying molecular pathways remain underexplored. This study aims to identify endometriosis-a…

BACKGROUND: Recurrent implantation failure (RIF) remains a significant barrier in assisted reproductive technology (ART), where multiple transfers of high-quality embryos fail to achieve pregnancy. While embryo-related factors have been ext…

OBJECTIVE: To evaluate the effectiveness of various medications for the treatment of endometriosis-related pain through a network meta-analysis. DATA SOURCES: A comprehensive search was conducted in PubMed, Embase, Web of Science, and the …

BackgroundSeveral studies have demonstrated that pre-treatment with long-acting Gonadotropin-Releasing Hormone agonists (GnRHa) can significantly enhance the clinical pregnancy rate among recurrent implantation failure (RIF) patients. Inves…

BackgroundThis study aimed to evaluate the clinical outcomes of umbilical cord mesenchymal stem cell (UC-MSC) transplantation on ovarian function in women with premature ovarian insufficiency (POI), and its potential to improve in vitro fer…

BackgroundCystitis glandularis is a chronic inflammatory disease of the urinary system characterized by high recurrence rates, the reasons for which are still unknown.ObjectivesThis study aims to identify potential factors contributing to r…

This study addresses the challenges in the early diagnosis of deep infiltrating endometriosis (DIE) by exploring the potential role of the deubiquitinating enzyme USP14. By analyzing the GSE141549 dataset from the Gene Expression Omnibus (G…

BACKGROUND Previous studies have suggested that autophagy, a cellular process regulated by ATG7, plays a critical role in ovarian physiology and pathology. In this study, our objective was to examine ATG7 levels in women with and without po…

BackgroundSimnotrelvir is an oral 3-chymotrypsin-like protease inhibitor that has been found to have in vitro activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and potential efficacy in a phase 1B trial.MethodsIn…