Gian Franco Zannoni

No ORCID on file · 42 papers in corpus · active 2002-2026

Study types

  • article 20
  • review 6
  • letter 3
  • other 3
  • case-report 2

Condition tags

  • endometriosis 21
  • adenomyosis 8
  • infertility 2
  • disambig:endometritis 2
  • endometrioma 1
  • chronic_pelvic_pain 1
  • bowel_endometriosis 1
article 2026
·doi:10.6084/m9.figshare.32760643.v1

Adenomyosis is a benign uterine disease that has been associated with endometrial proliferative disorders. Adenomyosis and endometrial cancer (EC) are sex-steroid-dependent conditions that may coexist, but their estrogen receptor (ER) and p…

2026
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology ·doi:10.1080/09513590.2026.2692730

BACKGROUND: Adenomyosis is a benign uterine disease that has been associated with endometrial proliferative disorders. Adenomyosis and endometrial cancer (EC) are sex-steroid-dependent conditions that may coexist, but their estrogen recepto…

article 2026
·doi:10.6084/m9.figshare.32760643

Adenomyosis is a benign uterine disease that has been associated with endometrial proliferative disorders. Adenomyosis and endometrial cancer (EC) are sex-steroid-dependent conditions that may coexist, but their estrogen receptor (ER) and p…

article 2025
·doi:10.1158/1538-7445.ovarian25-pr018

Abstract Evidence suggests that certain histotypes of ovarian carcinoma -mainly clear cell (CCOC) and endometrioid (EOC) carcinoma-may arise from endometriosis (EAOC), although the biological mechanisms underlying this phenomenon remain unc…

other 2025
Facts, views & vision in ObGyn ·doi:10.52054/FVVO.2025.183

Hysteroscopic metroplasty improves reproductive outcomes in women with a dysmorphic uterus, but the impact of adenomyosis in these patients is uncertain. We retrospectively analysed 69 women who underwent metroplasty for a dysmorphic uterus…

case-report 2025
Pathologica ·doi:10.32074/1591-951X-1221

The AFF2 gene encodes a protein involved in transcriptional regulation and chromatin remodeling. While primarily associated with Fragile X syndrome, AFF2 fusions have recently been identified in certain malignancies, mostly sinonasal squamo…

2025
Virchows Archiv : an international journal of pathology ·doi:10.1007/s00428-024-03743-6

Sex cord-like endometrioid carcinoma (SCLEC) is an uncommon entity which may constitute a diagnostic challenge. This study aimed to perform a clinicopathological, immunohistochemical, and molecular reappraisal of ovarian SCLEC. Consecutive …

article 2024
·doi:10.1158/1538-7445.am2024-3647

Abstract Endometriosis represents a pressing medical concern, imposing a relevant burden on patients including potential malignant transformation into endometriosis-associated ovarian cancer (EAOC). Despite the process of cancer development…

2024
Virchows Archiv : an international journal of pathology ·doi:10.1007/s00428-023-03672-w
article 2023
·doi:10.1136/ijgc-2023-esgo.35
article 2023
Pathology, research and practice ·doi:10.1016/j.prp.2023.155062

HPV-independent in situ adenocarcinomas have been only recently added to the WHO 2020 classification. To date, little information has been published about HPVindependent precursor lesions. In particular, regardiong the extremely rare cervic…

letter 2023
Virchows Archiv : an international journal of pathology ·doi:10.1007/s00428-023-03659-7
meta-analysis 2023
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society ·doi:10.1136/ijgc-2022-004014

OBJECTIVE: In endometrial carcinoma patients, sentinel lymph node bilateral mapping fails in 20-25% of cases, with several factors affecting the likelihood of detection. However, pooled data about predictive factors of failure are lacking. …

2023
Biomedicines ·doi:10.3390/biomedicines11061714

Chronic endometritis (CE) is the persistent inflammation of the endometrial lining associated with infertility and various forms of reproductive failures. The diagnosis of CE is based on the histological evidence of stromal plasma cells; ho…

review 2022
Pathobiology : journal of immunopathology, molecular and cellular biology ·doi:10.1159/000521105

Background: A better endometrial cancer (EC) prognosis in patients with coexistent adenomyosis has been hypothesized based on a different prevalence of favorable EC histological prognostic factors. However, pooled risk of EC unfavorable his…

2022
Diagnostics (Basel, Switzerland) ·doi:10.3390/diagnostics12123146

Pilomatrix-like high-grade endometrioid carcinoma (PiMHEC) has recently been described as an aggressive variant of endometrial carcinoma. Herein, we described a case of ovarian PiMHEC, comparing it to endometrial PiMHEC and assessing previo…

2021
Diagnostics (Basel, Switzerland) ·doi:10.3390/diagnostics11040713

BackgroundTo date, useful diagnostic applications of p16 IHC have been documented in gynecological pathology both for HPV-related and non-HPV-related lesions. In the present article, we reported our experience with the novel anti-p16 INK4a …

review 2021
Cancers ·doi:10.3390/cancers13194918

A better endometrial cancer (EC) prognosis in patients with coexistent adenomyosis has been reported. Unfortunately, it is still unclear if this better prognosis is related to a more favorable clinical profile of adenomyosis patients. We ai…

review 2021
International Journal of Gynecology & Obstetrics ·doi:10.1002/ijgo.13818

BACKGROUND: Despite the high prevalence of adenomyosis in hysterectomy specimens of endometrial carcinoma (EC) patients, the relationship between adenomyosis and EC prognosis appears unclear. OBJECTIVE: To assess the prognostic value of coe…

article 2021
review 2020
Anticancer research ·doi:10.21873/anticanres.14212

Endometriosis is an estrogen-dependent disease, which affects 10% of women in the reproductive age. Malignant transformation is an uncommon event, which affects approximately 0.7-2.5% of women, and, when it occurs, it involves ovarian and e…

article 2020
Gynecologic and obstetric investigation ·doi:10.1159/000508225

INTRODUCTION: Endometriosis is a common benign gynecological condition that can be associated with a slightly increased risk of developing a wide range of malignancies. CASE PRESENTATION: We herein report a singular case of a 62-year-old wo…

other 2019
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society ·doi:10.1136/ijgc-2018-000045

OBJECTIVES: To describe sonographic features of the microcystic elongated and fragmented (MELF) pattern of myometrial invasion (MI) using the International Endometrial Tumor Analysis (IETA) criteria; to assess the effect of the MELF pattern…

2019
BMC cancer ·doi:10.1186/s12885-019-6318-5

BackgroundThe aim of this study was to assess the agreement rate between intraoperative evaluation (IOE) and final diagnosis (FD) in a series of surgically resected endometrial carcinoma (EC), with a preoperative ambiguous or inconclusive d…

review 2019
Gynecologic and obstetric investigation ·doi:10.1159/000499019

BACKGROUND: We reviewed published cases of uterus-like mass (U-LM), endomyometriosis, polypoid adenomyoma (PA), adenomyomatous polyp, atypical PA (APA), and adenomyoma. SEARCH METHODS: PubMed, Medline, and Scopus searches of all cases publi…