Phenotypical plasticity of endometriosis-related ovarian neoplasms

Francesca Addante, Antonio Travaglino, Damiano Arciuolo, Caterina Fulgione, Antonio Raffone, Angela Santoro, Gian Franco Zannoni
Virchows Archiv : an international journal of pathology · 2023 · vol. 487(6) , pp. 1445–1446 · doi:10.1007/s00428-023-03659-7 · PMID:37776349 · W4387216521
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This study investigated the phenotypical plasticity of ovarian neoplasms associated with endometriosis, as illustrated by a case with mixed endometrioid and clear cell carcinoma components and squamoid morules.

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This short Virchows Archiv paper discusses phenotypical plasticity in endometriosis-related ovarian neoplasms, focusing on how tumor morphology and differentiation can vary in ways that complicate histopathologic classification. It summarizes observations from endometriosis-associated ovarian tumors and emphasizes that multiple histologic patterns can coexist or change, reflecting plasticity rather than a single fixed phenotype. A key limitation is that, as presented here, the evidence is largely descriptive and based on case-based or overview discussion rather than a systematic, population-level analysis with defined endpoints. This paper is centrally about endometriosis-related ovarian neoplasms — specifically phenotypical plasticity of tumors arising in the context of endometriosis.

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Access this article We’re sorry, something doesn't seem to be working properly. Please try refreshing the page. If that doesn't work, please contact support so we can address the problem. Data Availability Additional data are available from the corresponding author upon reasonable request. References Xu J, Park KJ, Rehrauer WM, Weisman PS (2023) Mesonephric-like adenocarcinoma of the ovary with squamoid morular metaplasia, aberrant β-catenin expression, and concurrent FGFR2 and CTNNB1 mutations: a case report. Virchows Arch. https://doi.org/10.1007/s00428-023-03522-9 Euscher ED, Marques-Piubelli ML, Ramalingam P, Wistuba I, Lawson BC, Frumovitz M, Malpica A (2023) Extrauterine mesonephric-like carcinoma: a comprehensive single institution study of 33 cases. Am J Surg Pathol. https://doi.org/10.1097/PAS.0000000000002039 Arslanian E, Singh K, James Sung C, Quddus MR (2022) Somatic mutation analysis of mesonephric-like adenocarcinoma and associated putative precursor lesions: insight into pathogenesis and potential molecular treatment targets. Gynecol Oncol Rep 42:101049 Vroobel KM, McCluggage WG (2022) Ovarian clear cell tumors associated with seromucinous borderline tumor: a case series. Int J Gynecol Pathol 41(1):76–81 Stolnicu S, Bartalis RJ, Ye Q, Da Cruz PA, Weigelt B, Soslow RA (2023) Ovarian RASoma with mesonephric-like adenocarcinoma and mixed mullerian components: a case report with molecular analysis demonstrating multidirectional mullerian differentiation. Int J Gynecol Pathol. https://doi.org/10.1097/PGP.0000000000000935 Author information Authors and Affiliations Corresponding author Additional information Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Supplementary Information Below is the link to the electronic supplementary material. 428_2023_3659_MOESM1_ESM.bmp Supplementary file1 Case of mixed endometrioid and clear cell ovarian carcinoma (upper left panel) in which the clear cell component shows squamoid morules (upper right panel). Positivity for Napsin A highlights the clear cell glands (lower left panel), while positivity for CDX2 highlights the squamoid morules (lower right panel). (BMP 25008 KB) Rights and permissions About this article Cite this article Addante, F., Travaglino, A., Arciuolo, D. et al. Phenotypical plasticity of endometriosis-related ovarian neoplasms. Virchows Arch 487, 1445–1446 (2025). https://doi.org/10.1007/s00428-023-03659-7 Received: Revised: Accepted: Published: Version of record: Issue date: DOI: https://doi.org/10.1007/s00428-023-03659-7

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