Liu W

Oxidative stress is a significant factor affecting reproductive efficiency in dairy cows, contributing to conditions such as endometritis that impair fertility and milk production. This study investigates the molecular mechanisms by which b…

Infertility impacts 48 million couples globally, and accumulating evidence suggests that micronutrients potentially influence reproductive health. This Mendelian randomization study investigates causal relationships between 15 micronutrient…

This review article focuses on the role of choline in ovarian follicular development, regulated by nutrient-epigenetic interactions. Choline, a key feed additive, participates in DNA methylation and steroid hormone synthesis via its methyl …

The lack of accurate understanding of cellular physiology and pathophysiology during the WOI constitutes the major obstacle to correct diagnosis and treatment for patients with recurrent implantation failure (RIF). The role of cilia as one …

Potassium permanganate (KMnO4) is a commercially available antiseptic used in bovine intrauterine lavage to manage postpartum infections. Lipopolysaccharides (LPS) are well-studied for their ability to induce inflammation and oxidative stre…

RESEARCH QUESTION: To investigate the underlying mechanisms driving the opposing effects of transforming growth factor-beta 1 (TGFβ1) on the proliferation of control (CESCs) and ectopic (EESCs) endometrial stromal cells. DESIGN: Cell proli…

BackgroundThe Life's Essential 8 (LE8) score has been associated with various health outcomes, but its relationship with female infertility remains unclear.MethodsThis study investigated the relationship between LE8 and infertility in women…

BackgroundThis study aims to evaluate the impact of adjuvant chemotherapy on cancer-specific survival (CSS) and overall survival (OS) in patients with Stage IA ovarian clear cell carcinoma (OCCC) using data from the Surveillance, Epidemiolo…

BackgroundDiabetes mellitus (DM) is one of the most common endocrine disorders affecting various physiological systems and tissues, including the reproductive organs in men. However, the consequences of DM for male individuals undergoing as…

Endometrial dysfunction underlies many common gynecologic disorders, such as endometriosis, endometrial cancer, intrauterine adhesions, and endometritis, which affect many women around the world. Extracellular vesicles play an important rol…

BACKGROUND: Although recent studies have examined alcohol-attributable pancreatitis (AAP), the contributions of population growth, aging, and sociol demographic index (SDI)disparities remain insufficiently quantified.This study aimed to ass…

BackgroundUterine fibroids(UF), while histologically benign, constitute a pervasive yet inequitable epidemiological phenomenon characterized by disproportionately distributed morbidity burdens that correlate asymmetrically with regional dev…

BackgroundThis retrospective study aimed to examine the influence of hormonal and metabolic parameters across varying body mass index (BMI) levels on embryo quality and pregnancy outcomes in fresh embryo transfer cycles using assisted repro…

Sheep (Ovis aries) are valuable biomedical models for studying human reproductive biology, however, the transcriptional dynamics underlying their ovarian development remain insufficiently characterized. In this study, we profiled 61,649 sin…

Lactate is an indispensable substance in various cellular physiological functions and plays regulatory roles in different aspects of energy metabolism and signal transduction. Lactylation (Kla), a key pathway through which lactate exerts it…

Ming Wei,1 Weijun Liu,1– 3 Zhangqiang Zheng,1 Yun Liu,1 Xingzhou Zhang1 1Tianjin NanKai Hospital, Tianjin Medical University, Tianjin, People’s Republic of China; 2Department of Scientific Research, Tianjin Key Laboratory of Acute Abdomen D…

INTRODUCTION: Endometriosis is a prevalent chronic gynecological disease, characterized by the growth of endometrial glands and stroma outside the uterus and by the presence of chronic inflammatory lesions. This condition is one of the most…

RESEARCH QUESTION: What are the lipidomic alterations in the myometrial tissue from adenomyotic lesions? DESIGN: This was a two-centre, prospective, observational study conducted between July 2023 and June 2024. Forty-four premenopausal pa…

INTRODUCTION: Ovarian adenomyoma is a rare gynecological tumor with a high misdiagnosis rate, leading many patients to undergo unnecessary surgeries that may affect fertility. Menstrual abdominal pain is the most common symptom, and auxilia…

ObjectivesTo carry out a quantitative assessment of the therapeutic effect of Chinese herbal medicine (CHM), with Rehmannia glutinosa as the main ingredient, in treating perimenopausal syndrome (PMS) in breast cancer patients.MethodsRandomi…

Endometriosis, a prevalent gynecological disorder marked by ectopic growth of endometrial-like tissue, demonstrates malignant tumor-like properties including aggressive adhesion and invasiveness. Emerging evidence implicates roundabout guid…

OBJECTIVE: To assess the effectiveness of perioperative nursing interventions in improving outcomes and satisfaction for patients undergoing laparoscopic surgery for ovarian endometriosis. METHODS: From July 2021 to September 2022, 80 pati…

The NLRP3 inflammasome is a multi-subunit complex consisting of the NLRP3 receptor protein, apoptosis-associated speck-like protein (ASC), and the effector protein caspase-1. The activation mechanisms of the NLRP3 inflammasome are diverse a…

BackgroundIncreased expression of tribbles pseudokinase 3 (TRIB3), which is attributed to increased levels of free fatty acids in the follicular fluid of women with obesity, is correlated with reduced oocyte developmental competence. Connex…

Objective: To explore the age of onset and consultation, the main clinical manifestations, common types of combined malformations, the relationship of endometriosis, surgical prognosis and different types of proportion of adolescent female …