Liu W

The NLRP3 inflammasome is a multi-subunit complex consisting of the NLRP3 receptor protein, apoptosis-associated speck-like protein (ASC), and the effector protein caspase-1. The activation mechanisms of the NLRP3 inflammasome are diverse a…

BackgroundIncreased expression of tribbles pseudokinase 3 (TRIB3), which is attributed to increased levels of free fatty acids in the follicular fluid of women with obesity, is correlated with reduced oocyte developmental competence. Connex…

Objective: To explore the age of onset and consultation, the main clinical manifestations, common types of combined malformations, the relationship of endometriosis, surgical prognosis and different types of proportion of adolescent female …

Abstract Aim The Oxidative Balance Score (OBS) functions as a measure for gauging the oxidative stress condition, OBS has been utilized to assess the overall oxidants and antioxidants exposure status in various chronic disease studies, Gr…

BackgroundThis study aimed to analyze the relationship between physical activity and the risk of premenstrual syndrome among college students.MethodsEligible studies were searched from the PubMed, Web of Science, and Embase databases. The l…

BackgroundGenome instability plays a crucial role in promoting tumor development. Germline mutations in genes responsible for DNA repair are often associated with familial cancer syndromes. A noticeable exception is the CHEK1 gene. Despite …

Background and aimsChronic enteropathy associated with SLCO2A1 gene is a rare intestinal disease caused by loss-of-function SLCO2A1 mutations, with clinical and genetic characteristics remaining largely unknown, especially in Chinese patien…

The diagnosis and treatment of intestinal and urinary tract deep infiltrating endometriosis (DIE) remain challenging due to its multiple lesions and nonspecific symptoms and signs. This study retrospectively analyzed 72 cases of intestinal …

​Mucinous ovarian cancer (MOC) is characterized by high malignancy, poor prognosis and a high recurrence rate. Surgical adjuvant chemotherapy is the main treatment for MOC. The recurrence rate of advanced mucinous ovarian cancer following s…

BackgroundOsteosarcoma is one of the most common cancers worldwide. Intense efforts have been made to elucidate the pathogeny, but the mechanisms of osteosarcoma are still not well understood. We aimed to investigate the potential biomarker…

Growing research suggests that endometriosis and systemic lupus erythematosus (SLE) are both chronic inflammatory diseases and closely related, but no studies have explored their common molecular characteristics and underlying mechanisms. B…

Somatic mutations contribute to cancer development by altering the activity of enhancers. In the study, a total of 135 mutation-driven enhancers, which displayed significant chromatin accessibility changes, were identified as candidate risk…

ObjectiveThe objective of this retrospective cohort study is to investigate the impact of monitoring serum estradiol (E2) levels before progesterone administration within hormone replacement therapy (HRT) on pregnancy outcomes in women unde…

IntroductionUreaplasma urealyticum (UU) is a common pathogen associated with genital tract infections in infertile males. However, its impact on semen quality, embryo development, and in vitro fertilization (IVF) outcomes remains underexplo…

BACKGROUND: Smilax china L. (SCL) is a traditional herbal medicine for the potential treatment of intrauterine adhesion (IUA). However, the mechanisms of action have not yet been determined. In this study, we explored the effects and mechan…

IntroductionThe NLRP3 inflammasome has been implicated in the initiation of inflammation and tumorigenesis; however, its role in epithelial ovarian cancer (EOC) remains unclear.MethodsThis study employed high-throughput sequencing data, ELI…

BackgroundBody weight could be classified into underweight, normal weight and overweight according to percentage of body fat (%BF), and normal weight obesity (NWO) is defined as a normal BMI but a high %BF. While the impact of NWO in women …

BackgroundRecurrent pregnancy loss (RPL) frequently links to a prolonged endometrial receptivity (ER) window, leading to the implantation of non-viable embryos. Existing ER assessment methods face challenges in reliability and invasiveness.…

Through a comprehensive retrospective analysis of a 52-year-old woman with primary ovarian lymphoma (POL) and a review of similar cases over the past decade in the PubMed database, we gained several key insights into improving the understan…

BackgroundWomen with pre-existing cardiac conditions who undergo assisted reproductive technologies (ART) are believed to be at a heightened risk of cardiovascular events during both the treatment and pregnancy phases. An unresolved questio…

BACKGROUND: Medroxyprogesterone acetate (MPA), a synthetic progestogen, is extensively used for the treatment of various conditions, including contraception, irregular menstruation, functional uterine bleeding, and endometriosis. However, l…

ObjectiveTo investigate the association between thyroid dysfunction or thyroid autoimmunity (TAI) and diminished ovarian reserve (DOR).MethodsA total of 2,867 women undergoing their first in-vitro fertilization (IVF) cycle at Shenzhen Zhong…

ObjectiveThis study was conducted to determine the influence of the number of CD138+ cells in the proliferative endometrium on pregnancy outcomes.MethodsThis retrospective cohort study was conducted from January to August 2018. A total of 6…

The therapeutic efficacy of drugs is determined, to a certain extent, by the efficiency of drug delivery. The low efficiency of drug delivery systems (DDSs) is frequently associated with serious toxic side effects and can even prove fatal i…

Wilms tumor (WT) is the most common type of malignant abdominal tumor in children; it exhibits a high degree of malignancy, grow rapidly, and is prone to metastasis. This study aimed to construct a prognosis model based on anoikis-related g…