Jun Qin — Endo Lab

2020

Quantifying phase separation property of chromatin associated proteins under physiological conditions using anti-1,6-hexanediol index

·doi:10.1101/2020.12.07.415489

Background Liquid–liquid phase separation (LLPS) is an important organizing principle for biomolecular condensation and chromosome compartmentalization. However, while many proteins have been reported to undergo LLPS, quantitative and glob…

article 2018

The pathogenic role of estrogen receptor beta drives in endometriosis

·doi:10.1530/endoabs.54.oc5

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

article 2015

Estrogen Receptor β Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis

Cell ·doi:10.1016/j.cell.2015.10.034

Alterations in estrogen-mediated cellular signaling play an essential role in the pathogenesis of endometriosis. In addition to higher estrogen receptor (ER) β levels, enhanced ERβ activity was detected in endometriotic tissues, and the inh…

article 2015

The Dual Estrogen Receptor α Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety

Molecular pharmacology ·doi:10.1124/mol.115.100925

The conjugated estrogen /: bazedoxifene tissue-selective estrogen complex (TSEC) is designed to minimize the undesirable effects of estrogen in the uterus and breast tissues and to allow the beneficial effects of estrogen in other estrogen-…

article 2012

A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis

Nature medicine ·doi:10.1038/nm.2826

Endometriosis is considered to be an estrogen-dependent inflammatory disease, but its etiology is unclear. Thus far, a mechanistic role for steroid receptor coactivators (SRCs) in the progression of endometriosis has not been elucidated. An…