Lum A

No ORCID on file · 7 papers in corpus · active 2017-2025

Study types

  • article 5
  • other 1
  • preprint 1

Condition tags

  • endometriosis 6
  • die_deep_infiltrating 3
  • infertility 1
  • endometrioma 1
other 2025
The Journal of Pathology ·doi:10.1002/path.6433

Clear cell ovarian cancer (CCOC) is the second most common ovarian cancer subtype, accounting for 5%-11% of ovarian cancers in North America. Late-stage CCOC is associated with a worse prognosis compared to other ovarian cancer histotypes, …

article 2023
The journal of pathology. Clinical research ·doi:10.1002/cjp2.317

The clinical phenotype of somatic mutations in endometriosis is unknown. The objective was to determine whether somatic KRAS mutations were associated with greater disease burden in endometriosis (i.e. more severe subtypes and higher stage)…

article 2019
The Journal of Pathology ·doi:10.1002/path.5314

The advent of next generation sequencing has vastly improved the resolution of mutation detection, thereby both increasing the resolution of the analysis of cancer tissues and shining light on the existence of somatic driver mutations in no…

preprint 2019
·doi:10.1101/561050

Abstract The presence of somatic driver mutations in endometriosis has previously been believed to represent early events in transformation, however our group and others have described such mutations in roughly one-third of cases of deep in…

article 2018
Human Reproduction ·doi:10.1093/humrep/dey332

STUDY QUESTION: Does incisional endometriosis (IE) harbor somatic cancer-driver mutations? SUMMARY ANSWER: We found that approximately one-quarter of IE cases harbor somatic-cancer mutations, which commonly affect components of the MAPK/RAS…

article 2017
The New England journal of medicine ·doi:10.1056/nejmoa1614814

BACKGROUND: Endometriosis, defined as the presence of ectopic endometrial stroma and epithelium, affects approximately 10% of reproductive-age women and can cause pelvic pain and infertility. Endometriotic lesions are considered to be benig…

article 2017
Gynecologic oncology ·doi:10.1016/j.ygyno.2017.09.032

ObjectiveEndometrioid (ENOC) and clear cell ovarian carcinoma (CCOC) share a common precursor lesion, endometriosis, hence the designation endometriosis associated ovarian cancers (EAOC). Long interspersed nuclear element 1 (LINE-1 or L1), …