Hilary Critchley
ORCID: 0000-0003-1913-4044
· 113 papers in corpus
lab-animal
2011
Endometrial regeneration is mediated, at least in part, by the existence of a specialized somatic stem cell (SSC) population recently identified by several groups using the side population (SP) technique. We previously demonstrated that end…
review
2011
The role of sex steroid hormones in reproductive function in women is well established. However, in the last two decades it has been shown that receptors for estrogens, progesterone and androgens are expressed in non reproductive tissue /or…
other
2011
Malcolm G. Munro, MD, FRCS(c), FACOG Hilary O.D. Critchley, BSc (Hons), MB ChB (Hons), MD, FRCOG, FRANZCOG, FFSRH, FMedSci Ian S. Fraser, AO, MD, BSc (Hons), FRANZCOG, CREI, FRCOG, FFFP (Hon), DUa Ian Fraser is a Professor of Reproductive M…
lab-animal
2011
CONTEXT: The human endometrium has an exceptional capacity for repeated repair after menses, but its regulation remains undefined. Premenstrually, progesterone levels fall and prostaglandin (PG) F₂α synthesis increases, causing spiral arter…
other
2010
Tubal ectopic pregnancy (EP) is the most common cause of maternal mortality in the first trimester of pregnancy; however, its etiology is uncertain. In EP, embryo retention within the Fallopian tube (FT) is thought to be due to impaired smo…
2010
ObjectiveTo demonstrate expression and regulation of prokineticins (PROKs) and their receptors (PROKRs) in fallopian tube (FT) from women who are not pregnant and women with ectopic pregnancy (EP).DesignTissue analysis.SettingLarge United K…
2010
diagnostic-accuracy
2010
OBJECTIVE: To establish a novel serum marker for endometriosis, serum autoantibodies (autoAbs) were investigated using a proteomic approach.DESIGN: Retrospective study.SETTING: Departments of Molecular Pathology and Obstetrics and Gynecolog…
lab-animal
2010
Introduction: Endometriosis, defined as the growth of endometrial tissue outside \nthe uterine cavity is a common gynaecological disorder affecting 10-15% \nof women in their reproductive years. It is a major clinical problem causing in- \n…
review
2010
The discovery of the endometrial antiproliferative effect of PRMs was an important milestone in their development. It was also unexpected, as compounds on July 14,
rct
2010
BACKGROUND: The levonorgestrel-releasing intrauterine system (LNG-IUS) is a highly effective contraceptive. However, during early months of use unscheduled vaginal bleeding is common, sometimes leading to discontinuation. This study aimed t…
2010
2009
ContextSex steroid hormone receptor (SHR) dynamics are well-documented in human endometrium but have not been comprehensively studied in Fallopian tube (FT).ObjectiveThe aim of the study was to compare expression patterns and hormonal regul…
rct
2009
Current hormone replacement therapy may not optimize cardiovascular health in women with premature ovarian failure. We compared the effects of physiological and standard sex steroid replacement regimens on cardiovascular health in these wom…
other
2009
CONTEXT: Heavy menstrual bleeding (HMB; menorrhagia) impairs quality of life for women and requires medication or surgery. Because glucocorticoids inhibit angiogenesis in other organs, we hypothesized that endometrium of women with HMB is s…
2009
2009
review
2009
The human endometrium has the unique capacity to repeatedly repair and regenerate throughout a woman’s reproductive life. Aberrations in this highly coordinated sequence of cyclical injury and repair leads to menstrual disorders. However, m…
2009
other
2008
BACKGROUND: Embryo retention in the Fallopian tube (FT) is thought to lead to ectopic pregnancy (EP), a considerable cause of morbidity. In mice, genetic/pharmacological silencing of cannabinoid receptor Cnr1, encoding CB1, causes retention…
other
2008
BACKGROUND: Estrogen receptor related beta (ERRbeta, ESRRB/NR3B2) is an orphan receptor that shares significant sequence homology with estrogen receptors ERalpha and ERbeta. ERR family members are reported to exhibit constitutive transcript…
2008
other
2007
BACKGROUND: Although the mechanisms underlying the causes of heavy menstrual blood loss (MBL) remain to be elucidated, prostaglandins have been previously implicated. This study was initiated to elucidate a pattern of expression of the vari…
2007
rct
2007
BACKGROUND: Continuous administration of progesterone antagonists (PAs) results in endometrial suppression and amenorrhoea in several model systems. We compared the effects of intrauterine release of a highly specific PA, ZK230211, to those…