Juan Ignacio Bastón

No ORCID on file · 10 papers in corpus · active 2011-2022

Study types

  • article 9
  • preprint 1

Condition tags

  • endometriosis 9
  • infertility 3
article 2022
Endocrine disruptor hexachlorobenzene induces cell migration and invasion, and enhances aromatase expression levels in human endometrial stromal cells
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association ·doi:10.1016/j.fct.2022.112867

Endometriosis is the presence and growth of endometrial tissue outside of the uterus. Previous studies have suggested that endocrine disrupting chemicals such as organochlorine pesticides could be a risk factor for endometriosis. Hexachloro…

article 2019
PI3K/AKT pathway is altered in the endometriosis patient’s endometrium and presents differences according to severity stage
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology ·doi:10.1080/09513590.2019.1680627

Based on the inflammatory nature and hormone-dependency of endometriosis, PI3K/AKT signaling appears to influence its progression. Could the endometriosis stages be linked to differential changes in PI3K/AKT pathway regulation? The objectiv…

article 2018
Active compounds present inRosmarinus officinalis leaves andScutellaria baicalensis root evaluated as new therapeutic agents for endometriosis
Reproductive biomedicine online ·doi:10.1016/j.rbmo.2018.09.018

Research questionCan carnosic acid, (CA) rosmarinic acid (RA) and wogonin (WG) inhibit the growth of cultured human endometrial stromal cells and endometriotic-like lesions induced in a BALB/c model of endometriosis?DesignPrimary stromal ce…

preprint 2017
Protein expression and cellular localization of Estrogen Receptors alpha and beta in endometriosis-associated epithelial ovarian cancer cell lines
·doi:10.26226/morressier.5912d9e9d462b80292386d75
article 2017
TNFRp55 deficiency promotes the development of ectopic endometriotic-like lesions in mice
The Journal of endocrinology ·doi:10.1530/joe-17-0236

Endometriosis is an inflammatory disease depending on estradiol, with TNF-α being one of the most representative cytokines involved in its pathogenesis. TNF-α acts through its bond to the TNFRp55 and TNFRp75 membrane receptors. The aim of t…

article 2016
Enhanced cyclooxygenase-2 expression levels and metalloproteinase 2 and 9 activation by Hexachlorobenzene in human endometrial stromal cells
Biochemical pharmacology ·doi:10.1016/j.bcp.2016.03.024

Hexachlorobenzene (HCB) is an organochlorine pesticide that induces toxic reproductive effects in laboratory animals. It is a dioxin-like compound and a weak ligand of the aryl hydrocarbon receptor (AhR). Endometriosis is characterized by t…

article 2015
Interplay between Endometriosis and Pregnancy in a Mouse Model
PloS one ·doi:10.1371/journal.pone.0124900

OBJECTIVES: To evaluate the effect of endometriosis on fertility and the levels of the IL-2 and IFN-γ in the peritoneal fluid in a mouse model; to evaluate the effect of pregnancy on endometriotic lesion growth, apoptosis and cell prolifera…

article 2014
Targeting galectin‐1‐induced angiogenesis mitigates the severity of endometriosis
The Journal of Pathology ·doi:10.1002/path.4397

Endometriosis is characterized by the presence of endometrial tissue outside the uterus that causes severe pelvic pain and infertility in women of reproductive age. Although not completely understood, the pathophysiology of the disease invo…

article 2012
Natural therapies assessment for the treatment of endometriosis
Human Reproduction ·doi:10.1093/humrep/des369

STUDY QUESTION: Can resveratrol and epigallocatechin-3-gallate (EGCG) inhibit the growth and survival of endometriotic-like lesions in vivo in a BALB/c model of endometriosis, and in vitro in primary cultures of human endometrial epithelial…

article 2011
Caracterización del endometrio y del ambiente peritoneal de mujeres que padecen endometriosis: Estudios in vivo e in vitro de nuevas alternativas terapéuticaspara esta enfermedad

El tema de estudio de nuestro laboratorio es la endometriosis, patología benigna que afecta alrededor de un 15% de las mujeres en edad reproductiva y que se caracteriza por la presencia de tejido endometrial fuera de la cavidad uterina, pro…