Johannes L H Evers

Parazzini.F. (1994) Medical treatment for pelvic pain in endometriosis: an overview of studies on danazol, medroxyprogesterone acetate, gestrinone, and gonadotropin releasing hormone agonists. In

Quantification of benefits and harms of medical interventions should be based on high-quality evidence, which is not always the case in the endometriosis field. In many clinical circumstances, healthcare decisions in women with endometriosi…

3To whom correspondence should be addressed Screening for tubal factor subfertility by means of Chlamydia antibody testing (CAT) was introduced into the initial work-up of subfertile couples several years ago. The results reported, however,…

OBJECTIVE: To estimate patterns of publication of clinical trials of endometriosis registered in ClinicalTrials.gov and their associated characteristics. METHODS: Information on interventional clinical trials on endometriosis that were regi…

Endometriosis is defined as the presence of endometrial tissue outside the uterus. It affects 10-15% of women during reproductive age and has a big personal and social impact due to chronic pelvic pain, subfertility, loss of work-hours and …

In response to the pressing need for more efficacious and safer therapeutics for endometriosis, there have been numerous reports in the last decade of positive results from animal and in vitro studies of various compounds as potential thera…

As a general gynaecologist you see a 28 year old patient who presents with increasingly painful menstrual periods since she stopped oral contraceptives one year ago in order to conceive. Since intercourse is now also becoming painful, she d…

Tissue integrity of the regurgitated endometrium is pivotal to the development of endometriosis. Occult, submicroscopic lesions occur. Diagnostic laparoscopy may underestimate as well as overestimate the presence of endometriosis.

It is known that angiogenesis is of pivotal importance for the development of endometriosis. However, in the treatment of endometriosis patients, prevention of endometriosis lesion development only will not be sufficient as a therapy. Treat…

BACKGROUND: Matrix metalloproteinases (MMPs) are essential for extracellular matrix remodelling and may contribute to the development of endometriosis. Transplantation of endometrium onto the chicken chorioallantoic membrane (CAM) results i…

Peritoneal endometriosis is the result of ectopic implantation and growth of endometrium tissue that has been regurgitated into the abdominal cavity during menstruation. We have previously shown that menstrual effluent induces epithelial to…

BACKGROUND: Not all women with patent tubes develop clinically manifest endometriosis. Quality and quantity of endometrium in retrograde menstruation may be the determining factor in the development of the disease. We hypothesize that retro…